Survival in patients with oral and maxillofacial diffuse large B-cell lymphoma

The purpose of this study was to determine the survival and prognostic factors of patients with diffuse large B-cell lymphoma (DLBCL) of the oral cavity and maxillofacial region. Retrospectively, the clinical records of patients with a primary diagnosis of DLBCL of the oral cavity and maxillofacial region treated at the A.C. Camargo Hospital for Cancer, São Paulo, Brazil, between January 1980 and December 2005 were evaluated to determine (A) overall survival (OS) at 2 and 5 years and the individual survival percentage for each possible prognostic factor by means of the actuarial technique (also known as mortality tables), and the Kaplan Meier product limit method (which provided the survival value curves for each possible prognostic factor); (B) prognostic factors subject to univariate evaluation with the log-rank test (also known as Mantel-Cox), and multivariate analysis with Cox's regression model (all the variables together). The data were considered significant at p ≤ 0.05. From 1980 to 2005, 3513 new cases of lymphomas were treated, of which 151 (4.3%) occurred in the oral cavity and maxillofacial region. Of these 151 lesions, 48 were diffuse large B-cell lymphoma, with 64% for OS at 2 years and 45% for OS at 5 years. Of the variables studied as possible prognostic factors, multivariate analysis found the following variables have statistically significant values: age (p = 0.042), clinical stage (p = 0.007) and performance status (p = 0.031). These data suggest that patients have a higher risk of mortality if they are older, at a later clinical stage, and have a higher performance status.

Craniofacial morphometry for craniofacial implant / Morfometría craneofacial para implante craneofacial

Craniofacial implants are being increasingly used to treat patients with sequelae of oncological resections, trauma, and congenital deficiencies, among other issues. The aim of this investigation was to establish the minimum and maximum bone dimensions present in the most used places for the insertion of craniofacial implants. A descriptive study was designed analyzing 40 human skulls using cone-beam computed tomography; in the volumetric reconstruction the points most often used in clinical investigations for the insertion of implants were selected, representing the orbital, perinasal, zygomatic bone and periauricular regions, measuring the distance between the cortical bones on the sagittal, axial and coronal planes; comparisons between gender and with other investigations with a similar aim were also made. In the supraorbital area, values of 7.92+/-1.82 mm were found and in the lateral area values of 7.54+/-0.98 mm, allowing the placement of implants 5 or 6 mm in length. In the area of the zygomatic bone, dimensions of 10.4+/-2.35 mm were obtained, allowing the placement of implants 8 mm in length. In the periauricular area values were obtained of 2.93+/-0.55 mm in the superior region and 3.1+/-0.7 mm in the inferior region, whereas in the perinasal area implants 4 mm in length can be placed. We concluded that the craniomaxillofacial bone structure presents acceptable widths for the installation of implants; the periauricular region presents lower dimensions, with the possibility of intracranial communication in areas above the external auditory meatus...

Los implantes craneofaciales están siendo cada vez más utilizado para tratar a pacientes con secuelas de resecciones oncológicas, traumatismos, y deficiencias congénitas, entre otras. El objetivo de esta investigación fue establecer las dimensiones óseas mínimas y máximas presentes en los lugares más utilizados para la inserción de implantes craneofaciales. Se diseño un estudio descriptivo que analizó 40 cráneos humanos utilizando cono Tomografía computarizada Cone-Beam; en la reconstrucción volumétrica fueron seleccionados los puntos más utilizados en las investigaciones clínicas para la inserción de implantes, que representan la orbital, hueso perinasal, hueso cigomático y regiones periauriculares. La medición de la distancia entre los huesos corticales en los planos sagital, axial y coronal, y las comparaciones entre el sexo y otras investigaciones con el mismo objetivo fueron realizadas. En el área supraorbital, se encontraron valores de 7,92 +/- 1,82 mm y en las áreas laterales de 7,54 +/- 0,98 mm, lo que permite la colocación de implantes de 5 o 6 mm de longitud. En el área del hueso cigomático se obtuvieron,dimensiones de 10,4 +/- 2,35 mm, permitiendo la colocación de los implantes de 8 mm de longitud. En la región periauricular se obtuvieron valores de 2,93 +/- 0,55 mm en la región superior y 3,1 +/- 0,7 mm en la región inferior, mientras que en lo zona perinasal se puede colocar implantes de 4 mm de longitud. Llegamos a la conclusión de que la estructura de los huesos craneomaxilofaciales presenta anchos aceptables para la instalación de implantes; la región periauricular presenta menores dimensiones, con la posibilidad de comunicación intracraneal en zonas sobre el meato auditivo externo...