ABSTRACT
Objective: In this study, we determined the relationship between the ambulatory arterial stiffness index [AASI] and clinical and laboratory parameters in patients with acromegaly
Methods: Sixty-five patients with acromegaly, who visited to Dicle University Medical Faculty Department of Endocrinology [33 females and 32 males], were included in this study. The study control group consisted of 65 subjects. Demographic and clinical data were recorded. Laboratory data [complete blood count, blood urea nitrogen, creatinine, electrolytes, albumin, lipid profile, growth hormone [GH], insulin-like growth factor-1, and the 75-g oral glucose tolerance test] performed over the last year were evaluated. The AASI was obtained from 24-hour ambulatory blood pressure monitoring records of all patients. This study was completed in 15 months from 2013 to 2015
Results: Twelve patients [18.4%] had diabetes and 21 patients [32%] had hypertension. The mean AASI value was 0.41 +/- 0.14. The mean AASI value in the control group was 0.25 +/- 0.09. Growth hormone [GH] levels were positively correlated with the AASI values. AASI values tended to be higher in hypertensive subjects than that in normotensive individuals
Conclusions: Our results show that the AASI value increased in patients with acromegaly, independent of the increase in blood pressure. The AASI was strongly dependent on the degree of the GH increase in patients with acromegaly and may have an important role predicting cardiovascular risk in patients with acromegaly
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Vascular Stiffness , Hypertension , Cardiovascular Diseases , Acromegaly/diagnosis , Growth HormoneABSTRACT
Objectives: The aim of this study was to investigate the relationships between clinical features of rheumatic diseases and hematologic indices, including mean platelet volume [MPV], MPV/platelet ratio [MPR], platelet/lymphocyte ratio, and neutrophil/lymphocyte ratio [NLR]
Subjects and Methods: Rheumatoid arthritis [RA; n = 91], systemic lupus erythematosus [SLE; n = 51], systemic sclerosis [SSc; n = 39], and Behcet's disease [BD; n = 53] patients, and 55 healthy controls [HC] were enrolled. Hematological indices were calculated and one-way analysis of variance, Mann-Whitney U and chi 2 tests, and receiver operating characteristic [ROC] analyses were performed
Results: The MPV and MPR were higher in the SLE group than the RA group [p < 0.05 and p < 0.01, respectively]. ROC analysis indicated that MPV [area under the curve, AUC, 0.68, 95% CI 0.58-0.77] and MPR [AUC 0.69, 95% CI 0.59-0.78] were sensitive and specific markers for SLE against RA. The NLR was higher in the RA, SLE, and SSc groups compared to the HC group [p < 0.05, p < 0.001, and p < 0.01, respectively]. The NLR was higher in the active BD patients than those that were inactive [p = 0.008]. Besides, NLR was higher in patients with neuro-BD and patients with active genital ulcers compared to patients without neurological involvement [p < 0.01] and active genital ulcers [p < 0.05]
Conclusion: The MPV and MPR were significantly higher in the SLE group than in the RA group. They were also higher in the active than in the inactive BD patients. The MPV and MPR are useful diagnostic tools for SLE, and NLR reflects disease activity in BD. However, further research should be performed to standardize these tools