ABSTRACT
Thyroglobulin (TG) is a protein that synthesized from the thyroid follicular epithelium and can reflect the thyroid gland in origin together with the cellular activity. The aim of this study is to detect TG qualitatively and semiquantitatively by immunoperoxidase method in various thyroid lesions. The result shows that all of the nodular goitre (43 cases), primary diffuse hyperplasia (18 cases), adenoma 60 cases, papillary carcinoma (43 cases) and follicular carcinoma (22 cases) show cytoplasmic staining of TG in varying pattern and intensity, while only 3 out of the 7 anaplastic carcinoma show irregular cytoplasmic staining. These findings can be used in identifying the thyroid gland in origin in the metastatic lesion and the functional status of the lesion.
ABSTRACT
Sections from 13 hepatocellular carcinomas (HCCs) were examined to determine the myofibroblasts (MFBs) in tumour fibrous stroma and cirrhotic fibrous stroma, using monoclonal antibodies to specific actins HHF-35, 1A4 and sarcomeric actin. Histological grading of tumours with the expression of a labelling index using monoclonal antibodies to proliferative cell nuclear antigen (PC-10) were correlated with the amount of MFBs. The results showed a statistically significant increase in the amount of MFBs in tumour fibrous stroma. However, no significant correlation was found between the amount of MFBs with histological grading or the labelling index. However, a good correlation with statistically significant differences between the histological grading of HCC with the labelling index was shown. In conclusion, MFBs found in the tumour fibrous septa of HCC were a response by the stromal reaction or a desmoplastic reaction intended to limit the tumour size by contraction.