ABSTRACT
OBJECTIVE@#To investigate the antitumor effect of maesopsin 4-O-β-glucoside (TAT2) isolated from the leaves of Artocarpus tonkinensis (A. tonkinensis) A. Chev. ex Gagnep.@*METHODS@#The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma (LLC) tumor-bearing mice. BALB/c mice had tumors induced by implantation with 2 × 10(6) LLC cells into the subcutaneous right posterior flank. Tumor-bearing mice were treated orally with a range of doses of TAT2 and a standard drug, doxorubicin. Animals were observed for tumor growth and mortality rate. Blood was collected to determine hematological and biochemical parameters.@*RESULTS@#TAT2 was isolated from an ethanolic extract of A. tonkinensis leaves. Its structure was determined by MS and NMR spectroscopy, and identified as TAT2. The compound did not show acute toxicity at the highest dose tested (2000 mg/kg body weight). TAT2 exhibited antitumor activity by decreasing tumor growth, increasing the survival rate, and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight (P < 0.05).@*CONCLUSIONS@#These results indicate that TAT2 possesses clear antitumor activity. Due to its bioavailability and low toxicity, and the fact that it could be isolated in a large scale from A. tonkinensis leaves, the compound shows promise as a potential anticancer drug.
ABSTRACT
Objective: To investigate the antitumor effect of maesopsin 4-O-β-glucoside (TAT2) isolated from the leaves of Artocarpus tonkinensis (A. tonkinensis) A. Chev. ex Gagnep. Methods: The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma (LLC) tumor-bearing mice. BALB/c mice had tumors induced by implantation with 2 × 10
ABSTRACT
Recently, treatment for bacillary dysentery have meet many difficulty due to Shigella which antibiotic resistance. Most of Shigella strains also resistant to many antibiotics at the same time (multi-antibiotics). The aim of the research is finding out genes that are encoded antibiotic resistance, features about structure, activity mechanism as well as transmitable of the genes in community. Material and method: researched strains: 100 S.flexneri strains, standard strain: E.coli K12-J5-3. Tecnology: diffused paper slice. The result chosen Sflexneri strains that resistant multi-antibiotic from 237 primary strains. Among them, 100 strains have major resistant type is resistant to 5 kinds of antibiotic. The strains are chosen to receive to E.coli K12J5-3. The percentage of receipt are 56%. Most of receive type don’t get enough resistance to the 5 antibiotics.