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Objective:To investigate the effect of bundles of care on pediatric hypnosis by rectal chloral hydrate.Method:A total of 368 children aged 0 to 3 years old who were treated in Dalian Children′s Hospital from December 2018 to June 2019 and were treated with chloralhydrate enemas were randomly divided into the control group (routine nursing intervention) and observation groups (bundled Intervention) 184 cases each. The chloralhydrate enemas were inserted for sedation, and the observation group added sedation while chloralhydrate enemas for sedation. After admission, record the data of each patient, and do the Ramsay sedation score after sedation. According to the sedation score, the sedation failure rate of chloralhydrate enema was increased, and the proportion of each score in the group was compared.Results:Ramsay sedation scores of the observation group and the control group after enema were 5.42 ± 1.34 and 3.14 ± 1.21, respectively. There was significant difference between the two groups ( t value was 2.08, P<0.05). The failure rates in experimental group and control group were 13.59% (25/184) and 38.59% (71/184), respectively. There was a significant difference between two groups ( χ2 value was 29.82, P<0.05). Conclusion:Bundles of care could decrease the failure rate of rectal chloral hydrate hypnosis significantly, then reduce the suffering of children. It is worth being widely used in clinic.
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Objective To develop a convolutional neural network （CNN） that can identify isokinetic knee exercises moment of force-time diagrams under different levels of efforts. Methods The 200 healthy young volunteers performed concentric isokinetic right knee flexion-extension reciprocating exercises with maximal effort as well as half the effort at angular velocities of 30°/s and 60°/s twice, respectively, with an interval of 45 min. The moment of force-time diagrams were collected. The 200 subjects were randomly divided into the training set （140 subjects） and the testing set （60 subjects）. The moment of force-time diagrams from subjects in the training set were used to train CNN model, and then the fully trained model was used to predict types of curves from the testing set. Random sampling of subjects along with subsequent development of models were performed 3 times. Results Under the circumstances of isokinetic knee exercises with maximal effort and half the effort, 2 400 moment of force-time diagrams were produced, respectively. Classification accuracy rates of the CNN models after the 3 trainings were 91.11%, 90.49% and 92.08%, respectively, and the average accuracy rate was 91.23%. Conclusion The CNN models developed in this study have a good effect on differentiating isokinetic moment of force-time diagrams of maximal effort exercises from those made with half the effort, which can contribute to identifying levels of efforts exerted by subjects during isokinetic knee exercises.
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Humans , Knee , Knee Joint , Muscle Contraction , Muscle, Skeletal , Neural Networks, ComputerABSTRACT
Objective:To study the efficacy and safety of natural calcined bone repair material(NCBM)in repairing bone defect af-ter tooth extraction.Methods:A randemized,double-blinded,parallel,positive control(Bio-Oss)and multi-center clinical trial was employed.Imaging examination was used as the main efficacy evaluation index,surgical wound healing,rejection reaction,bone me-tabolic changes,bone infection signs were the subordinate efficacy evaluation indexes,the incidence of adverse reactions was observed for safety evaluation.Results:280 cases were included,269 cases completed the trial.In NCBMand Bio-Oss group the effective rate of imaging examination was 93.08% and 93.70%(P >0.05)respectively.The wound healing time of the 2 groups was less than 7 days,no rejection reaction,bone metabolic change and bone infection sign were observed.The incidence of adverse events in NCBM and the Bio-Oss group was 0.72% and 2.14%(P >0.05)respectively.Conclusion:The efficacy and safety between natural cal-cined bone repair material is not inferior to Bio-Oss in repairing bone defect after tooth extraction.
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Objective: To establish an HPLC fingerprint of anthraquinone components and to provide the basis for quality standard and processing principle of processed Morinda officinalis (Morindae Officinalis Radix). Methods: HPLC method was employed and Ecosil ODS C18 column (250 mm × 4.6 mm, 5 μm) was used at temperature of 28°C. The mobile phase was methanol-0.1% phosphoric acid solution with gradient elution. The detection wavelength was 277 nm. The experimental data were analyzed by computer aided similarity evaluation software. Results: HPLC fingerprint for anthraquinone components of different processed products of M. officinalis was established. Five chromatographic peaks of M. officinalis, morinda pulp, and salt-steamed M. officinalis and six chromatographic peaks of licorice-processed M. officinalis were respectively identified. The quality difference of M. officinalis among ten-origins reached significant level. The difference of anthraquinone components was not significant among the various processed products, but the content was changed. Liquiritigenin was found in licorice-processed M. officinalis. Conclusion: The method is accurate, repeatable, and reliable, which can be used to identify different processed M. officinalis.
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The literatures of classic and modern application of herbal juice , like ginger juice, licorice juice, rice water, evodia rutaecarpa juice, black soya bean juice, bile, etc were collected.The history and successive changes of the processing research of herbal juice used as processing excipient were summarized , which could offer the reference to the modern processing excipient of herbal juice .
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The original teaching of clinical pharmacy for stomatology course did not let students aware of the importance of drugs in the treatment of oral diseases. The original teaching framework was rearranged:decentralizing knowledge of oral diseased related clinical pharmacy into several mod-ules;setting general knowledge into the oral basic medical module;adding the practice of visiting the pharmacy and manufacturing laboratory. Teaching process was closely combined with clinics and was integrated with disease-centered oral medicine curriculum integration system. Students responded that the teaching effect was better. The rearranged teaching method can enhance students' attention on drug treatment for oral diseases,improve their ability of clinical medication and promote the teaching quality.