ABSTRACT
Reversion mutations are associated with clinical resistance to poly(ADP-ribose) polymerase inhibitors (PARPi). Here, we describe the detection of a BRCA1 reversion mutation in a 39-year-old woman with metastatic breast cancer harboring a heterozygous germline BRCA1 exons 7–8 deletion who received PARPi olaparib combined with immune checkpoint inhibitor camrelizumab as third-line therapy. During progression from the olaparib and camrelizumab combination therapy, we identified via genomic sequencing a novel 7-base pair somatic deletion in BRCA1 (c.617_623delACAAATC). Sequence analyses indicated that this mutation realigned the reading frame of BRCA1, which potentially led to the reversal of its normal function and conferred resistance to PARPi.
ABSTRACT
The paper aimed to find out the present situation of bilingual teaching in higher medical education of the local medical college for nationalities and the results of the questionnaire showed that there were still some problems in the bilingual teaching education in these years.And some constructive suggestions were put forward.
ABSTRACT
The paper aimed to find out the present situation of English teaching for non-English Majors under multimedia and network environment in Southwest Minority Area by means of the questionnaire.And the results of the questionnaire showed that there were still some teaching problems in the new reform of the college English teaching in these years,so some constructive suggestions were put forward