Research progress and utilization strategy on alkaloid resource chemistry of Coptidis Rhizoma / 中草药

Coptidis Rhizoma is one of the staple traditional Chinese medicinal materails in China with long officinal history, and its alkaloids provide the most important sources of precursor compounds in innovative drug research, which has been the focus of industry attention. This paper emphasized the industry development and summarized the alkaloid resource chemical constituents in Coptidis Rhizoma, and the progress of resource chemical research on Coptidis Rhizoma based on quality evaluation, structure modification and industrial application of the alkaloids was analyzed. The attention to the high value development of resource compounds and the use of “non-traditional medicinal tissues” for the limited resource Coptidis Rhizoma were proposed. The utilization ways and strategies provide important reference for the comprehensive development and resource recycling of Coptidis Rhizoma.

Immunological Activities of Components from Leaves of Liriodendron chinensis / 中草药·英文版

Objectives: To investigate the anti-inflammatory components from the leaves of Liriodendron chinensis. Methods: The 95% alcohol extract from the leaves of L. chinensis was subjected to column chromatography, and the structures of purified compounds were determined by spectral methods. The bioassay was performed through the inhibitory effects on the inflammatory cells activated by lipopolysaccharide (LPS). Results: Nine compounds were isolated, including octacosanoic acid (1), stearic acid (2), (2 R)-2-hydroxy-N-[(2 S,3 S,4 R,8 E)-1,3,4-tri-hydroxyicos-8-en-2-yl]tetracosanamide (3), (2 R)-2-hydroxy-N-[(2 S,3 S,4 R,8 E)-1-O-ß-D-glucopyranosyloxy-3,4-dihydroxyoctadec-8-en-2-yl]eicosanamide (4), (2 R)-2-hydroxy-N-[(2 S,3 S,4 R,8 E)-1-O-ß-Dglucopyranosyloxy-3,4-dihydroxyoctadec-8-en-2-yl]hexadecanamide (5), dicentrinone (6), liriodenine (7), daucosterol (8), and liriodendritol (9) and among which five compounds could significantly lower the content of nitric oxide (NO) from peritoneal macrophages of rats induced by LPS and reduce the splenic lymphocyte proliferation in mice. This is the first report on the occurrence of ceramides and dicentrinone in the plants of Liriodendron Linn. Conclusion: The five compounds are likely to be anti-inflammatory compounds concerning to their pronounced inhibitory action on the activated inflammatory cells. This assessment might provide a basis for searching the potent active compounds used for the treatment of inflammation.

Chemical study on aerial parts of Ligusticum chuanxiong / 中国中药杂志

<p><b>OBJECTIVE</b>To study the chemical constituents of the aerial parts of Liusticum chuanxiong.</p><p><b>METHOD</b>The chemical components were isolated by silica gel and Sephadex LH-20 column chromatography. Structures were elucidated on the basis of physico-chemical properities and spectral data.</p><p><b>RESULT</b>Eight chemical constituents were isolated, and identified as protocatechuic acid (1), caffeic acid (2), scopoletin (3), apigenin (4), quercetin (5), cosmosiin (6), kaempferol-3-O-beta-D-glucopyranosid (7) and glucose (8).</p><p><b>CONCLUSION</b>Compounds 1-8 were obtained from the aerial parts of the plant for the first time, compounds 3-8 were obtained from the plant for the first time.</p>

Studies on involatile constituents of Mentha haplocalyx / 中国中药杂志

<p><b>OBJECTIVE</b>To promote its comprehensive utilization, the involatile constituents of Mentha haplocalyx were studied systematically.</p><p><b>METHOD</b>The chemical components were isolated and purified by silca gel column chromatography and recrystallization. The chemical structures were elucidated on the basis of physico-chemical properties and spectral data.</p><p><b>RESULT</b>Eight compounds were isolated and identified as: acacetin (I), tilianine (II), linarin (III), n-butyl-beta-D-fructopyranoside (IV), ursolic acid (V), oleanolic acid (VI), beta-sitosterol (VII), daucosterol (VIII).</p><p><b>CONCLUSION</b>Compounds I approximately V were obtained from this plant for the first time.</p>

Chemical constituents of Glechoma longituba / 药学学报

<p><b>AIM</b>To study the chemical constituents of Glechoma longituba (Nakai) Kupr.</p><p><b>METHODS</b>Manifold chromatography methods were used to separated the chemical constituents, and the chemical structures were determined by spectral analyses.</p><p><b>RESULTS</b>Nine compounds were isolated from Glechoma longituba and identified, as: glecholone (1), 6R,9R-3-oxo-alpha-ionol (2), S(+)-dehydrovomifoliol (3), vomifoliol (4), corosolic acid (5), quercetin (6), stigmastenol (7), myristic acid (8) and triacontanol (9).</p><p><b>CONCLUSION</b>Compound 1 is a new compound. Compounds 2 - 9 were isolated from this plant for the first time.</p>

Study on the flavonoids of Eupatorium lindleyanum / 中国中药杂志

<p><b>OBJECTIVE</b>Study on the flavonoids from the air part of Eupatorium lindleyanum.</p><p><b>METHOD</b>Alcohol percolation, silica gel column chromatography and re-crystallization et al.</p><p><b>RESULT</b>Jaceosidin, kaempferol, quceritin, astragalin, trifolin and hypersoide were isolated from E. lindleyanum. Their structures were elucidated on the basis of spectral evidence.</p><p><b>CONCLUSION</b>Jaceosidin, kaempferol, quceritin, astragalin and trifolin were isolated from E. lindleyanum for the first time.</p>

Study on the anticancer activities (in vivo) of the extract from Citrus reticulata Blanco and its influence on sarcoma-180 cells cycle / 中国中药杂志

<p><b>OBJECTIVE</b>To study the anticancer activity of the extract from Citrus reticulata in vivo.</p><p><b>METHOD</b>Anticancer activities were tested with tumor model in vivo (Sarcoma-180 cells, Heps cells, EAC cells implanted in mice).</p><p><b>RESULT</b>The extract from Citrus reticulata showed marked anticancer activities on Sarcoma-180 cells and Heps cells implanted in mice, had no marked anticancer activities on EAC cells implanted in mice and induced apoptosis of Sarcoma-180 cell.</p><p><b>CONCLUSION</b>The extract from Citrus reticulata will have promising prospects as an anticancer Chinese medicine, but further studies will be needed.</p>