Preparation and anticancer activity of temsirolimus:research advances / 国际药学研究杂志

Notwithstanding the noteworthy advances in its treatment,malignant tumor remains one of the main diseases threat?ening human health. Therefore,it is urgent to search and develop novel anticancer drugs with high curative effect and less side effect. In this review,we focus on summarizing the physio-chemical properties,preparation processes,anti-tumor activity mechanisms,clini?cal effects,side effects,and main isomers,especially the research progress of temsirolimus,with the hope to provide some reference for the further research.