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1.
Ashok AGARWAL; Neel PAREKH; Manesh-Kumar PANNER-SELVAM; Ralf HENKEL; Rupin SHAH; Sheryl-T HOMA; Ranjith RAMASAMY; Edmund KO; Kelton TREMELLEN; Sandro ESTEVES; Ahmad MAJZOUB; Juan-G ALVAREZ; David-K GARDNER; Channa-N JAYASENA; Jonathan-W RAMSAY; Chak-Lam CHO; Ramadan SALEH; Denny SAKKAS; James-M HOTALING; Scott-D LUNDY; Sarah VIJ; Joel MARMAR; Jaime GOSALVEZ; Edmund SABANEGH; Hyun-Jun PARK; Armand ZINI; Parviz KAVOUSSI; Sava MICIC; Ryan SMITH; Gian-Maria BUSETTO; Mustafa-Emre BAKIRCIOĞLU; Gerhard HAIDL; Giancarlo BALERCIA; Nicolás-Garrido PUCHALT; Moncef BEN-KHALIFA; Nicholas TADROS; Jackson KIRKMAN-BROWNE; Sergey MOSKOVTSEV; Xuefeng HUANG; Edson BORGES; Daniel FRANKEN; Natan BAR-CHAMA; Yoshiharu MORIMOTO; Kazuhisa TOMITA; Vasan-Satya SRINI; Willem OMBELET; Elisabetta BALDI; Monica MURATORI; Yasushi YUMURA; Sandro LA-VIGNERA; Raghavender KOSGI; Marlon-P MARTINEZ; Donald-P EVENSON; Daniel-Suslik ZYLBERSZTEJN; Matheus ROQUE; Marcello COCUZZA; Marcelo VIEIRA; Assaf BEN-MEIR; Raoul ORVIETO; Eliahu LEVITAS; Amir WISER; Mohamed ARAFA; Vineet MALHOTRA; Sijo-Joseph PAREKATTIL; Haitham ELBARDISI; Luiz CARVALHO; Rima DADA; Christophe SIFER; Pankaj TALWAR; Ahmet GUDELOGLU; Ahmed-M-A MAHMOUD; Khaled TERRAS; Chadi YAZBECK; Bojanic NEBOJSA; Damayanthi DURAIRAJANAYAGAM; Ajina MOUNIR; Linda-G KAHN; Saradha BASKARAN; Rishma-Dhillon PAI; Donatella PAOLI; Kristian LEISEGANG; Mohamed-Reza MOEIN; Sonia MALIK; Onder YAMAN; Luna SAMANTA; Fouad BAYANE; Sunil-K JINDAL; Muammer KENDIRCI; Baris ALTAY; Dragoljub PEROVIC; Avi HARLEV.
The World Journal of Men's Health ; : 296-312, 2019.
Article in English | WPRIM | ID: wpr-761886

ABSTRACT

Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.


Subject(s)
Female , Humans , Male , Antioxidants , Classification , Clinical Protocols , Diagnosis , DNA , Embryonic Structures , Fertility , Health Expenditures , Infertility , Infertility, Male , Membranes , Ovum , Oxidants , Oxidation-Reduction , Oxidative Stress , Reactive Oxygen Species , Reducing Agents , Reproductive Health , Semen , Spermatozoa , Subject Headings
2.
Asian Journal of Andrology ; (6): 498-504, 2018.
Article in English | WPRIM | ID: wpr-1009618

ABSTRACT

Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo quality, and assisted reproduction success. A total of 81 semen samples and 635 embryos from couples undergoing oocyte donation cycles at the IVI Bilbao Clinic were analyzed. Semen parameters, embryos quality, and blastocyst development were examined according to the World Health Organization standards and the Spanish Association of Reproduction Biology Studies criteria. The percentage of testicular angiotensin-converting enzyme-positive spermatozoa and the number of molecules per spermatozoon were analyzed by flow cytometry. Both parameters were inversely correlated with human sperm motility. Higher percentages of testicular angiotensin-converting enzyme-positive spermatozoa together with fewer enzyme molecules per spermatozoon were positively correlated with better embryo quality and development. Our results suggest that embryos with a higher implantation potential come from semen samples with higher percentages of testicular angiotensin-converting enzyme-positive cells and fewer enzyme molecules per spermatozoon. Based on these findings, we propose that testicular angiotensin-converting enzyme could be used to aid embryologists in selecting better semen samples for obtaining high-quality blastocysts during in vitro fertilization procedures.


Subject(s)
Adult , Humans , Male , Middle Aged , Embryo Implantation/physiology , Embryo Transfer , Embryonic Development/physiology , Fertility/physiology , Fertilization in Vitro , Peptidyl-Dipeptidase A/metabolism , Sperm Motility/physiology , Spermatozoa/enzymology , Testis/enzymology
3.
Asian Journal of Andrology ; (6): 1-8, 2018.
Article in English | WPRIM | ID: wpr-1009526

ABSTRACT

Spermatozoa retrieved from the testis of men with high levels of sperm DNA fragmentation (SDF) in the neat semen tend to have better DNA quality. Given the negative impact of SDF on the outcomes of Assisted Reproductive Technology (ART), an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection (Testi-ICSI). In this article, we used a SWOT (strengths, weaknesses, opportunities, and threats) analysis to summarize the advantages and drawbacks of this intervention. The rationale of Testi-ICSI is bypass posttesticular DNA fragmentation caused by oxidative stress during sperm transit through the epididymis. Hence, oocyte fertilization by genomically intact testicular spermatozoa may be optimized, thus increasing the chances of creating a normal embryonic genome and the likelihood of achieving a live birth, as recently demonstrated in men with high SDF. However, there is still limited evidence as regards the clinical efficacy of Testi-ICSI, thus creating opportunities for further confirmatory clinical research as well as investigation of Testi-ICSI in clinical scenarios other than high SDF. Furthermore, Testi-ICSI can be compared to other laboratory preparation methods for deselecting sperm with damaged DNA. At present, the available literature supports the use of testicular sperm when performing ICSI in infertile couples whose male partners have posttesticular SDF. Due to inherent risks of sperm retrieval, Testi-ICSI should be offered when less invasive treatments for alleviating DNA damage have failed. A call for continuous monitoring is nonetheless required concerning the health of generated offspring and the potential complications of sperm retrieval.


Subject(s)
Adult , Female , Humans , Male , Pregnancy , DNA Fragmentation , Infertility, Male , Pregnancy Outcome , Sperm Injections, Intracytoplasmic/methods , Sperm Retrieval , Spermatozoa , Testis/cytology
4.
Asian Journal of Andrology ; (6): 59-65, 2004.
Article in English | WPRIM | ID: wpr-300864

ABSTRACT

Oxidative stress is a common condition suffered by biological systems in aerobic conditions. Human semen also has its own molecular guard against the free radicals created by normal respiratory process or from immune reactions. The equilibrium of the creation and scavenging of free radicals is mandatory in the spermatozoa to fertilize and initiate a full-term pregnancy. The paper is a systematic review of publications that evaluate oxidative stress in semen. The Cochrane Library, Medline (1966-2003), Embase (1988-2003), SciSearch (1981-2003) and the conference papers were searched. When sperm samples from fertile and infertile males were analyzed, some of the mechanisms that determine the oxidative stress level were found to be impaired while others were unaltered. In conclusion, the literature as a whole provides contradictory findings and it is necessary to carry out more work to identify all the enzymatic and non-enzymatic systems involved in oxidative stress in the ejaculate, in order to develop new diagnostic systems and therapeutic strategies for combating detrimental free radical imbalance in the semen.


Subject(s)
Humans , Male , Antioxidants , Metabolism , Fertility , Infertility, Male , Metabolism , Oxidants , Metabolism , Oxidative Stress , Reactive Oxygen Species , Metabolism , Semen , Chemistry , Metabolism , Spermatozoa , Metabolism
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