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Rev. méd. Chile ; 123(2): 158-64, feb. 1995. tab
Article in Spanish | LILACS | ID: lil-151168

ABSTRACT

The possible hypertensive effect of oral contraceptives is a controversial issue. We studied 371 women, admitted to the family planning program of a atate funded outpatient clinic, that were followed during 12 months. These women were divided in 4 groups. Group 1 was constituted by 98 women that used intrauterine devices. Group 2 by 98 women taking 30 µg of estrogen and 300 µg of progestogen. Group 3 by 83 women taking 35 µg of estrogen and 500 µg of progestogen and Group 4 by 92 puerperal women taking 30 µg of levonorgestrel, that after six month started to use an intrauterine device (n=35) or the contraceptives of group 2 (n=38) or group 3 (n=19). Age, initial blood pressure and weight were similar in the 4 groups. There was no significant change in blood pressure after 6 or 12 centrations up to 35 µg and progestogen concentrations between 300 and 500 µg do not induced changes in blood pressure


Subject(s)
Humans , Female , Adult , Contraceptives, Oral/pharmacokinetics , Blood Pressure , Body Weight/drug effects , Randomized Controlled Trials as Topic , Estradiol Congeners/pharmacokinetics
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