ABSTRACT
Literature review indicates that antibiotic resistance of bacteria may be associated with the resistance to host natural immunity. In the previous study we found that: all meningococcal isolates of meningitis cases are less sensitive to typical anti-meningococcal antibiotics. In present study, the association of the above characters was analyzed in an ex-vivo "case-control" study. A randomized controlled trial compared effect two dietary treatments [low glycemic index and low fat] in 46 adults, ages 18-55 years old, BMI >27,who proceed to motahary clinic in shiraz, Iran. Body weight, BMI, WHR [waist/hip ratio], fast and post-prandial Plasma lipid profile [Triacylglycerol, total Cholesterol, LDL-C, HDL-C concentration] level of obese women measured at the beginning and at the end 6 weeks. The resistance of both groups against selected sera were similar in the ratio 1:2- by SIC and SBC methods. The growth of "test" and "control" groups in the pooled sera were stopped at the ratios 1:512 and 1:1024 respectively. In SB A the population of "test" and "control" groups decreased in parallel to each other. However, the invasive [test] meningococcal strains established slower reduction in WBA. Studies on the correlation between antibiotic resistance of bacteria and the resistance to the natural immunity have ended with different results. According to our experience, it seems that for ex- vivo investigation of natural immunity against meningococci the WBA is more reliable