ABSTRACT
<p><b>OBJECTIVE</b>To compare the cutaneous permeation of Kechuan acupoint patch and power, and evaluate the possibility of dosage form reform of Kechuan recipe.</p><p><b>METHOD</b>Take the Eugend and Ephedrine as the indexes, HPLC was employed to determine their contents, the pond with Franz diffusion were used to measured the cutaneous.</p><p><b>RESULT</b>The permeation of Patch matched with Higuchi Equation. Take Eugend as the index, the permeation rate of total of Patch is 2.319 and 1.738 times of the powder, and 1.784 and 1.215 times of the powder with the Ephedrineas as index.</p><p><b>CONCLUSION</b>The permeation rate of Kechuan acupoint patch was more rapid than the powder. Moreover, the total quantity of permeation of patch was also more than the powder.</p>
Subject(s)
Animals , Rabbits , Acupuncture Points , Administration, Cutaneous , Anti-Asthmatic Agents , Pharmacokinetics , Chromatography, High Pressure Liquid , Drug Combinations , Drugs, Chinese Herbal , Chemistry , Pharmacokinetics , Ephedrine , Pharmacokinetics , Eugenol , Pharmacokinetics , In Vitro Techniques , Permeability , Plants, Medicinal , Chemistry , Powders , Skin , Metabolism , Skin AbsorptionABSTRACT
Objective To improre typieal proeedure of UPPP,increase clinical effects and deerease complioations caused by the operation.Methods Twenty eight patients with obstructive sleep apnea syndrome who had been confirmed by PSG in our hospital from 2003 to 2005 were involved in this study.1)improving stripping method:the fat and tonsil were removed by electric knife.2)improving molding method:the muscle of uvula was maitained,but the fat was removed;mucous and the tissue under it were double-layer sutured.3) the data before and 6 months after UPPP were analyzed by questionnaire and polysomnography(PSG)detection.Result No fissuration occurred.The distance between soft palate and posterior wall was 3?0.6 before operation and it was 6?0.8 6 months after operation.The effect is 100% based on the questionnaire investigation and PSG detection.Conclusions 1)Hemostasis of electric knife was reliable;2)Double-layer suture of mucous and the tissue under it can avoid hemorrhage and insure molding of pharyngeal cavity;3)The results of the uvula preservation can improve the effect of the UPPP by increasing the nasopharyngeal and oropharyngeal cavity,and avoiding velopalatal insufficiency.