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From January 1989 to December 1993, 53,526 cervical smears were studied to detect common specifec infection including fungus, Trichomonas, Leptothrix, HSV and HPV infection in Cytology Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen Uiversity. The prevalence of fungus, Trichomonas, Leptothrix, HSV add HPV infection were 17.9% 0.1%, 0.1% and 0.5% respectively. In the 3,414 abnormal Pap smear, the coexisted infection of fungus, Trichomonas, Leptothrix, HSV and HPV infection were 10.2%, 3.5%, 0.1%, 0.7% and 7.5% respectively. It is noted that, most of these infection could be detected alone much more than coexisting with abnormal Pap smear, except HPV infection where all cases coexisted with abnormal Pap smear. And HSV infection that occurred alone was 55.8% comparing to infection associated with abnormal Pap smear was 44.2% , which is about the same proportion. The diagnosis of these micro – organism in Pap smear is useful for routine screening examination in the large population study . It is useful in convincing the clinician to pay special attention to the patients, who had HPV and HSV infection. They were considered to be a high risk patients for cervical cancer who should be closely followed in order to detect precncerous lesion which can be satisfactory treated.
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The cytopathology results of 698 fine needle aspirations (FNA) of thyroid nodules from the patients who visited Srinagarind Hospital from January 1984 to July 1990 were analyzed. Five hundred FNA (71.6%) were cytologically benign, 40 FNA (5.7%) were suspicious for malignacy, 21 FNA (30%) were malignant, and 137 FNA (19.6%) were unsatisfactory. The histologic diagnosis in 101 cases were compared with cytologic diagnosis to determine the accuracy of Fna cytology of thyroid lesions. From 24 diagnosis of malignancy reported by histology, 14 malignancies, 1 suspicious lesion, 2 benign lesions and 7 cystic lesions were found by FNA. No false positive were recorded. Sensitivity, specificity and accuracy of FNA diagnoses were 87.5%, 100% and 96.15%, respectively.
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Comparative study of VCE and cervical scraping Pap smears of the uterine cervices was done in 470 OPD cases in Srinagarind Hospital from October 1987 to January 1990. The cervical scraping Pap smear had low sensitivity in detecting endocervical cells and atypical cells when compared with the VCE technique (34.7% and 23.3% respectively), but had high sensitivity in detecting dysplastic cells (72.7%). However, in the VCE slides the cervical scraping parts © were the most sensitive parts to detect dysplastic cells.
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Comparative study malignant cells in effusion by wright’s stain and papanicoloau stain were done on 546 cases. Malignant cells were diagnosed 156 cases (100%) from both wright’s stain and papanicoloau stain, 154 cases (98.7%) from papanicoloau stain and 153 cases (98.1%) from wright’s stain, Type of malignancy were squamous cell carcinoma (0.6%), adenocarcinoma (91.7%), small cell carcinoma (1.9%), lymphoma (4.5%) and multiple myeloma (1.3%)
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Objective: To compare the cytologic diagnosis of a liquid-base, Thin-layer preparation and conventional cervical smear.Material and Method: Ninety nine cervical smears were processed conventional method and with the ThinPrepÒ Pap test. Cytologic diagnosis based on the Bethesda system 2001.Results: Of the 99 pair slides of conventional and ThinPrep Pap test smears interpreted during the study period. All smears were cytologic diagnosed as negative for intraepithelial lesion or malignancy (90 conventional and 85 ThinPrep smears), atypical squamous cells of undertermined significance, ASC-US (1 conventional and 5 ThinPrep smears), low-grade squamous intraepithelial lesion, LSIL (0 conventional and 2 ThinPrep smears), high-grade squamous intraepithelial lesion, HSIL (4 conventional and 3 ThinPrep smears), Invasive cervical cancer (4 agreement by conventional and ThinPrep smears).Conclusion: The ThinPrep Pap test is more sensitive method of detecting ASC-US and squamous intraepithelial lesion than the conventional Pap smear in this preliminary study.
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Objective: To assess the histologic correlates of atypical squamous cells of undetermined significance (ASCUS) Pap smear and analyze its impact on the accuracy of Pap smear. Study design: A total of 7,546 women were screened for early detection of cervical cancer. The women with ASCUS diagnosis were further qualified as ASCUS favor reactive, ASCUS favor LSIL (low grade squamous intraepithelial lesion) and ASC-H (cannot exclude HSIL) according to the Bethesda 1991 system and the Bethesda 2001 system of reporting. ASCUS favor reactive were followed up by a repeat smear examination and persistent ASCUS cases were taken up for colposcopy and biopsy if indicated. All ASCUS favor LSIL and ASC-H cases were taken up for immediate colposcopy. Results: On cytohistologic correlation of diagnosed ASCUS cases, the total 80 ASCUS favor reactive cases, 37 showed chronic cervicitis with or without squamous metaplasia, the accuracy 50.41%. The total 24 ASCUS favor LSIL, 8 showed HPV (human papilloma virus) infection/ CIN 1 (cervical intraepithelial neoplasia)/ CIN1+HPV infection, the accuracy 77.24%. The total 19 ASC-H, 5 showed CIN2 / CIN3 / CIN2, CIN3 + HPV infection, the accuracy 85.36%. Conclusion: Our data showed a good accuracy in ASC-H group. ASCUS is a problem to define, diagnose, reproduce and manage. The diagnosis of ASCUS is wide, ranging from a totally chronic cervicitis, HPV infection and CIN. Careful attention to subtle cytomorphologic characteristics may be helpful for a more definitive subdivision of ASCUS terminology into ASC-US and ASC-H.