Stability of sulphacetamide sodium in eye preparations

The effects of light, temperature, pH and additives on the stability of Sulphacetamide sodium in eye preparations have been studied. The Sulphacetamide eye drops are stable at room temperature and lose potency at elevated temperature. The stability is also affected by light and pH of the solution. The eye drops are more stable when Sodium mctnbisulphitc and Phenyl mercuric nitrate are used as preservatives