ABSTRACT
Niaodukang is an effective formula used in the second affiliated hospithal of Guangzhou Universityof TCM for chronic renal failure, which is composed of Rhizoma Rhei,Radix Polygoni Multiflori,Radix Astragali seu Hedysari and Fructus Ligustri Lucidi with the actions of supplementing qi, warmingYang, strengthening spleen, tonifying kidney, promoting blood circulation and removing turbid pathogenicfactor. To explore the effect of Niaodukang on the lipid metabolism of chronic renal faiure, rat model wasset up with improved technique of 5/6 kidney mass removal. After the accomplishment of the rat model for2 weeks, the models matched with the geneal conditions and 24 hours' proteinuria were randomly allocated to five groups: the model group,two Niaodukang groups with high and low dosages respectively, CoatedAldehyde Oxystarch group and the nounal control group. Serum contents of triglyceride, cholesterol andapoprotein were tested.The results showed that the blood lipid level in the model group was higher than thenormal group,and decreased markedly after the treatment of Niaodukang. It is indicated that Niaodukang exerts a good effect on the blood-lipid metabolism in rat model with chronic renal failure.