ABSTRACT
To study quality of life in Systemic Lupus Erythematosus patients. And to assess the impact of the psychological state on quality of life in a group from these patients. The study included 50 patients with systemic lupus, Including 40 subjects divided into 20 normal control and 20 subjects with depressive disorders from the same age group. Who were subjected to Hamilton depression rating scale [HDRS], Minnesota Multiphase Personality Inventory [MMPI], Rating scales for psychopathological health status and Quality of life Scale. [PCASEE] questionnaire. There are statistically significant differences between SLE patients with psychiatric manifestations and those without psychiatric manifestations as regards the [HDRS] and [MMPI] scales regarding depression, hysteria, hypochondrasis, paranoia, psychoathenia, schizophrenia, social introversion, psychopathic, hypomania. Also, there is statistically significant difference between the patients group and control group regarding the total score of the physical item [somatic items] regarding quality of life scale. Also, there are statistically significant differences between both groups as regards economic problems, at affective problems and cognitive problems according to [PCASEE]. Quality of life in SLE patients with psychiatric manifestations was more impaired than the SLE patients without psychiatric manifestations in the following items: economic problems, cognitive functions and affective problems. That may help in explain that the psychiatric manifestation increase the degree of impairment and disability in patients of SLE. Also, SLE patients are more impaired in quality of life than the group of depression as regards the economic problems