ABSTRACT
To detect the most common psychiatric manifestations associated with systemic lupus Erythematosus. Also, to correlate between psychiatric manifestations and immunity. The study included 50 patients with systemic lupus, Including 40 subjects divided into 20 normal control and 20 subjects with depressive disorders who were subjected to Hamilton depression rating scale [HDRS], Minnesota MuItiphase Personality Inventory [MMPI], Immunological tests to detect immunogloblins IgG, IgM and antiribosomal P protein antibodies. The total frequency of antiribosomal antibodies in the group of SLE patients was [38%] compared to the group of control depression only one patient is strong positive while the group of normal control no persons are positive. All depressed patients had high serum level of IgG and 93.3% of the control normal had a higher level of IgG while 88% of the SLE patients had high lgG serum levels 28% of the SLE patients had high IgM serum levels compared to both groups of depression and control normal with no statistically significant. Also, there are non significant negative correlations between antiribosomal antibodies and paranoia, schizophrenia and non significant positive correlations between the antiribosomal antibodies and depression detected by NI MMPI. There are highly significant positive correlations between depression and the lgG. While there are significant negative correlations between the IgM and depression. There are statistically significant differences between SLE with psychiatric manifestations and SLE without psychiatric manifestations regarding HDRS and MMPI. There is high frequency of psychiatric manifestations in SLE patients and depression considered the most frequent psychiatric disorders in SLE patients. There are strong relation between disturbance in the immune system and psychiatric disorders proved by high level of immunogloblins in patients with depression. Also, there are high frequency of antiribosomal antibodies in patients of SLE but their relations with the development of psychiatric symptoms are still contradictory