ABSTRACT
The most common reason for discontinuing use of Depo-Provera contraceptive is due to their association with menstrual disorders. The injectable hormonal contraceptive Cyclofem has been marketed worldwide to reduce menstrual disorders such as spotting and amenorrhea. How extent of these methods can be effective in reducing these disorders is unclear. This study was conducted in order to compare the effectiveness of Cyclofem and Depo-provera on menstrual bleeding patterns. In this clinical trial, 64 women [30 Person in Cyclofem users group and 34 Person in Depo-Provera users group] with normal menstrual blood flow participated, Candidate were placed in two groups randomly. The first injection of Depo-Provera and Cyclofem was administered within the first 5 days of menstrual cycle. Bleeding events of women were recorded in the menstrual diary card during these three months and then collected data were analyzed by SPSS software version 18. At the end of 3 months, 76.7% of the group who received Cyclofem and 55.9% Depo-Provera users had normal menstrual cycles. Irregular bleeding was the most common presenting abnormal pattern for both groups [20-26%]. Average of bleeding and spotting days was 21 +/- 2.5 in Cyclofem and 22 +/- 1.9 in Depo-Provera. However, there was no significant difference between groups. This study have been prove that in the first three months of use of Cyclofem and Depo-Provera, there were no significant difference in bleeding patterns menstrual