Influence of salivary pH on the sorption rate of nano-filled composite resin.

Background: Physical properties of a resin composite are as important for the longevity of composite material as the mechanical properties are for its survival in the oral environment. Objectives: The aim of this study is to evaluate the effect of artificial saliva with different pH (4.6, 5.1, 5.7, 6.3, 6.9, 7.5 & 8.1) on the sorption of dental nano-filled composites. Material and Methods: 5 disc shaped specimens were made for each group of pH with nano-filled composite resin and immersed for four weeks. Optical density was measured in Ultraviolet Vis Spectrophotometer. Statistical one-way analysis of variance (one-way ANOVA) and the two-way analysis of variance (ANOVA) were used throughout this study. Results: No significant differences were detected in specimens of any group of pH. Conclusions: Salivary pH has no effect on the nano-filled dental composite material. Future research needs to test more experimental designs that could depict the clinical behavior of the restorative material in vitro environment.

Sublingual human insulin for hyperglycaemia in type l diabetes

OBJECTIVE: To investigate the hypoglycaemic effects of repeated sublingual doses of human insulin for the treatment of hyperglycaemia in type I diabetes. DESIGN: Clinical trial. SETTING: A Private clinic. METHOD: Eight insulin dependent diabetic males with a mean age of 27 years [range 18-32 years] presenting with hyperglycaemia were given 1 U/Kg body weight of human soluble insulin in 5 equally divided doses at 15 min intervals, sublingually. Plasma glucose was estimated at 0, 15, 30, 45, 60, 90, 120 and 150 min. Urine examination for glucose was done at 45 min intervals. The results showed that the mean plasma glucose before treatment was 19.93 + 2.1 mmol/L Hypoglycaemic effect was recorded at 15 min and reached a peak at 120 min when plasma glucose dropped to 10.9 + 1.2 mmol/L [p < 0.001]. No side effect was reported and insulin was tolerated well. We concluded that sublingual human insulin in repeated doses has a hypoglycaemic effect and could be used to control hyperglycaemia in type I diabetes

Peritoneal macrophages transfusion in the treatment of chronic postoperative wound infections

Four patients with chronic post-operative wound infections and wound gapping that failed to respond to antibiotics were treated by allogeneic macrophage transfusions. No harmful effects were observed following macrophage transfusion and the chronic infections were eradicated in the treated patients with complete healing of wounds. Haemoglobin and white cell count were increased after cell transfusion.It could be concluded that allogeneic macrophage transfusion can combat chronic resistant infections and stimulate both wound healing and haemopoiesis

Three cases of nephrotic syndrome treated by indomethacin

Three cases of nephrotic syndrome treated by indomethacin, either oral capsules or rectal suppositories, are presented. Results showed that indomethacin caused marked reduction in proteinuria and frequency of micturition, loss of oedema fluid and elevation of serum albumin and total protein. These effects were continued after withdrawal of indomethacin in two patients. It could be concluded that indomethacin might have a place in the management of proteinuria, hypoalbuminemia and frequency of prostaglandins are discussed

Psoriasis treated with high dose oral indomethacin

Two patients with psoriasis were treated with indomethacin. One patient showed marked relief and at 18 months follow-up was uneventful, whilst the other showed mild improvement. The mode of action of indomethacin and the role of prostaglandins in the disease are discussed

Treatment of advanced chorionic carcinoma with indomethacin and steroids: case report

A patient with advanced chorionic carcinoma was treated with cytotoxic drugs, methotrexate and 6-mercaptopurine for a period of three months. Her general condition, including physical, laboratory and radiological findings, deteriorated during and after treatment. She was then given 75 mg of indomethacin and 15 mg of prednisolone daily; signs of improvement, both clinical and radiological, were noted after four weeks of this treatment. It might be concluded that this therapy contributed successfully to the course of her disease and her well-being