ABSTRACT
Background: Ovarian superovulation and increased follicle-stimulating hormone concentration for infertility treatment may be the risk factors of developed granulosa-cell tumor. The aim of this report is to introduce a case of granulosa-cell
tumor which was discovered after ovarian stimulation
Case: A 31-yr-old woman with clinical presentation of massive abdominal distention was referred to the gynecology and oncology department of an academic hospital, Mashhad University of Medical Sciences in Aug 2017. She had the history of secondary infertility and was undergoing In Vitro Fertilization protocol and ovarian stimulation, but, the cycle was canceled. The patient suffered from gradual abdominal distention one month after the end of IVF procedure despite pregnancy failure. 2-3 months after management of the ovarian hyperstimulation syndrome, investigation revealed large ovarian mass and increased tumor marker inhibin. Exploratory laparotomy was performed and revealed stage III ovarian cancer. The final pathology report indicated juvenile granulosa cell tumor. So, optimal surgical staging and cytoreductive surgery without fertility preserving were perfumed. Chemotherapy was recommended due to the advanced stage of ovarian cancer. Unfortunately, she experienced metastatic diseases in pelvic and abdomen in less than six months; and currently is receiving the second and third line chemotherapy
Conclusion: Persistent ovarian enlargement or ascites during or after infertility treatment should be carefully considered and managed
ABSTRACT
Introduction: Uterine arteriovenous malformation [AVM] following molar pregnancy is a rare condition. The present study aimed at reporting a case of uterine arteriovenous malformation after molar pregnancy
Case Presentation: A 38-year-old woman with repeated heavy vaginal bleeding was referred to oncology department of Ghaem hospital affiliated to Mashhad University of Medical Sciences in 2016. She had history of evacuation curettage of molar pregnancy in the previous month. Examinations revealed AVM in fundus of uterus; and the patients was asymptomatic after embolization of the AVM and she is now under serial follow-up
Conclusions: The diagnosis of AVM should be considered when an unexplained massive hemorrhage occurs after gestational trophoblastic disease. In the case of correct diagnosis, unnecessary surgery is avoided