Co-relation of lactic dehydrogenase levels with severity of pre-eclampsia

The elevated levels of LDH may reflect the severity of pre-eclampsia and occurance of complications. This study was carried out as a comparative study at Social Security Teaching Hospital, Lahore from June 2004 to January 2006: A total of 120 pregnant women with preeclempsia [60 with mild and 60 with severe pre-eclampsia] and 60 healthy normotensive controls were included in the study. The total number of deliveries during the same period was 5402. The patients were divided in three groups after admission through outpatient and emergency departments. Group I: [n-60] third trimester healthy pregnant women. Group II: [n-6o] women with mild pre-eclampsia. Group III: [n-60] women with had severe pre-eclampsia. The three groups were matched according to the age, parity, gravidity, maternal weight, haemodyanamic and laboratory tests. A statistically significant difference in terms of age, weight and parity were noticed in 3 groups p <0.05. Primigravida were 20% in normotensives, 40% were with mild pre-eclampsia and 60% with severe pre-eclamptia. In comparison of group II and III [severe pre-eclampsia] showed a statistically significant increase in terms of LDH and liver enzymes [p<0.05] in group III. LDH levels >600 IU/l were seen in 62% of women with severe pre-eclampsia compared to 10% in group I and II woman. LDH concentrations >800 IU/1 had significant increase in frequency of epigastric pain and vomiting and no significant difference in other system. Severe pre-eclampsia with LDH >800 IU/l women had significant increase in all complications noticed, eclampsia being the most frequent one. Elevated levels of LDH, indicative of cellular damage, can be used as a biochemical marker because it reflects complications and foetal outcome

VBAC; its safety and outcome

An observational, prospective study of 509 pregnant women presenting to Unit-3, Department of Gynecology and Obstetrics, Sir Ganga Ram Hospital/Fatima Jinnah Medical College during one year starting from February 2005 was carried out. Aim of the study was to assess the safety of VBAC [Vaginal Birth After Cesarean], and its final outcome, in patients who had previously undergone a Cesarean Section, with or without a history of a previous successful vaginal delivery. The data analysis and results showed VBAC was successful in a significant number of women, indicating that even women who have had previous CS should be strongly considered for vaginal deliveries in any of the subsequent pregnancy

Women with pregnancy induced hypertension; epidemiological differences between normotensive pregnant women

To identify the epidemiological differences between normotensive pregnant women and women in pregnancy induced hypertension. A descriptive analytical case control study. Department of Obs and Gynae of Sir Ganga Ram Hospital Lahore. From January to December 2004. 2 groups with 100 patients in each were studied. PIH is more common in young, obese, primigravidas with a family or past history of PIH or hypertension and in those with poor socioeconomic status and no regular dietary calcium supplementation

Maternal risk factors in early onset septicemia

This study was done to find out the association between the maternal risk factors like premature onset of labor [POL], prolonged rupture of membranes [PROM], and chorioamnionitis [CA] and subsequent development of early onset sepsis in the newborn. Of 129 patients studied 58 [44.96] developed sepsis. Premature onset of labor, prolonged rupture of membranes, and chorioamnionitis Present in 41[31.89%], 91[70.5%], 71[55.0%] respectively and sepsis developed in 30[73%], 42[46.5%], 1[51.47%] respectively. Two risk factors namely POL, ROM was present in 21 and 17[80.95%] babies developed sepsis. POL and CA was present in 13 and 12[92.30%] had sepsis. PROM and CA was present in 50 and 35[70%] had sepsis. Three risk factors POL, PROM, CA were present in 10 and 9[90%] developed sepsis. This indicates that presence of multiple maternal risk factors make a child more susceptible to have early onset neonatal sepsis