ABSTRACT
In von Recklinghausen's disease vascular involvement is rare, especially rupture of peripheral arterial aneurysms. A 65-year-old man with previously diagnosed neurofibromatosis was admitted because of left lateral neck and left shoulder pain. Computed tomography and selective left subclavian angiography revealed ruptured aneurysm of left costocervical artery, and therefore an emergency operation was performed. Left costocervical artery was exposed and proximal ligation of the aneurysm was performed. Angiography is a most useful and important procedure in operations for vascular involvement in von Recklinghausen's disease.
ABSTRACT
A 61-year-old man with aortic regurgitation was found to have a quadricuspid aortic valve during operation. The aortic valve consisted of four equal sized cusps with an accessory cusp located between the left and right coronary cusps. The right coronary ostium was placed in a lower position. Aortic replacement with a St. Jude Medical prosthesis was performed successfully. Quadricuspid aortic valve is a rare anomaly and 14 cases of quadricuspid aortic valves in the Japanese literature which were corrected surgically are reviewed.
ABSTRACT
To investigate the efficacy of human superoxide dismutase (h-SOD) in myocardial ischemia and reperfusion with difference of administration of h-SOD, twenty four dogs were subjected to 120min ischemia by the cross clamping of the ascending aorta, and followed by 60min reperfusion, The dogs were randomly assigned to three groups: group G, h-SOD (8mg/kg) was injected into the cardiopulmonary bypass (CPB) circuit 5min prior to reperfusion; group L, h-SOD (3mg/kg) was administered by bolus injection through the aortic root into the coronary artery 1min prior to reperfusion; group C, nothing was administered. The values of creatinine phosphate MB isozyme (CPK-MB) and a-hydroxydehydrogenase (HBD) in coronary effluent, and lipid peroxides (LPO) in coronary artery and sinus blood, were measured during CPB. Cardiac function was evaluated by cardiac index (C. I.) and LV max <i>d<sub>p</sub>/d<sub>t</sub></i>, and it was expressed as a percent recovery of pre-CPB state. Myocardial water contents as myocardial edema were measured after CPB. Effluents of CPK-MB and HBD at 60min after reperfusion were less in group L than group G, C. Generations of LPO (A-Cs difference) were less at 5min after reperfusion in group G, L than group C and there were significant differences between group G, L and group C. The percent recovery of C. I. and LV max <i>d<sub>p</sub>/d<sub>t</sub></i> at 60min after reperfusion was superior in group G, L than group C and there were significant difference between group G, L and group C. Myocardial water contents at 60min after reperfusion were less in group G, L than group C and there were significant difference between group G, L and group C. In the lipid peroxides generation, cardiac function and myocardial edema except effluents of cardiac enzymes, group G was as well as group L. These data suggest that the injection of h-SOD into the CPB circuit just before reperfusion is effective to prevent the reperfusion injury as well as the administration through the aortic root.