ABSTRACT
To determine the post menopausal changes of pulse pressure in the early age menopause women. A cross sectional and comparative study, was performed at the department of Physiology B.M.S.I., J.P.M.C., Karachi in collaboration with the Abbassi Shaheed Hospital and National Institute for Cardiovascular Diseases, Karachi. This study included a total of 100 women, 50 with early age post menopause and 50 with normal age post menopause. For the statistical analysis, the degree of probability was computed by comparing the calculated value of "t" with tabulated value in the table of "t" distribution against the degree of freedom. Pulse pressure was found to be significantly increased with a P-value of <0.001 in the early age post menopause women. This suggests that an early age post menopause is more likely to develop a marker of preclinical cardiovascular disease such as increased pulse pressure