ABSTRACT
Neonatal septicaemia is a common cause of morbidity and mortality in developing countries and a major health concern. The aim of this study is to evaluate the bacterial profile; antibiotics susceptibility pattern and associated risk factors of suspected septicaemia in neonates in this locality. Five hundred and forty seven consecutive blood samples from neonates admitted in the special baby care unit (SCBU); Aminu Kano Teaching Hospital (AKTH); Kano between January 2007 and December 2008 were cultured aerobically and anaerobically in the Microbiology Department; Aminu Kano Teaching Hospital by standard bacteriological methods. Antibiotic susceptibility pattern was done by disc diffusion methods. One hundred and fifty two (27.8) positive blood cultures were obtained from the present study. The most frequently isolated organism was Staphylococcus aureus (25.0) followed by Klebsiella pneumoniae (21.1) and Escherichia coli (15.0). Gentamicin; ofloxacin; ceftriaxone and amoxycillin/clavulanate showed higher percentage antibiotic sensitivity pattern while chloramphenicol; cotrimoxazole and ampicillin showed very low percentage antibiotic sensitivity pattern against the various bacterial isolates. The present study showed that Staphylococcus aureus is the leading isolate in neonatal septicaemia in Kano. Gentamicin and Ceftriaxone are recommended as first line drugs in the management of neonatal septicaemia in our locality
Subject(s)
Anti-Bacterial Agents , Developing Countries , Morbidity/mortality , Risk Factors , SepsisABSTRACT
Background: Nosocomial infection caused by methicillin resistant S. aureus (MRSA) presents with management difficulties in infected patients due to their resistance to a number of other frontline antibiotics and constitutes significant epidemiological problems. This study was undertaken to determine the prevalence of methicillin resistant S. aureus and antibiotic sensitivity pattern in clinical isolates in Kano. There is dearth of information on this subject in Kano. Method: One hundred and eighty five (185) S. aureus isolates from various clinical specimens obtained over a 12-month period in the Microbiology Department of Aminu Kano Teaching Hospital (AKTH) were subjected to methicillin susceptibility testing; while including susceptibility testing to other antibiotics by the disc diffusion methods. Result: Out of 185 S. aureus isolates tested; 53(28.6) were found to be methicillin resistant. While 38(62) isolates were obtained from in-patients; 15(28) were from out-patients. Surgical wound infection had the highest prevalence of 32(60) isolates. Antibiotics sensitivity results of methicillin susceptible staphylococcus aureus MSSA) and MRSA with the third generation cephalosporins and the quinilones were encouraging. All MRSA isolates were sensitive to vancomycin. Conclusion: A prevalence of 28.6MRSA in this environment calls for urgent intervention strategies due to its possible rapid spread and therapeutic problem