ABSTRACT
We report two pediatric cases of acute tubulointerstitial nephritis [ATIN]. The first case is a 13 year-old boy, with one month history of vomiting and fever treated with Bromure de butylhyoscine [Buscopan] and Sulpiride. He developed oliguric acute renal failure. ATIN was diagnosed by renal biopsy. He needed dialysis for 3 weeks and was treated successfully with steroids for 8 months. The second case is a 7 year-old boy, treated with Ceftriaxone for febrile diarrhaoe. Laboratory studies showed an eosinophilia and eosinophiluria. Renal histopathology revealed features of drug induced ATIN. The patient was treated with steroids and didn't require dialysis
ABSTRACT
The aim of this study is to evaluate the efficacity of immunosuppressive therapy in steroid - resistant idiopathic nephrotic syndrome. 30 children present to the renal biopsy a focal and segmental glomerulosclerosis [HSF 18 cases], minimal change disease [LGM: 9 cases] and diffuse mesangial proliferation [PMD: 3 cases]. 9 of 11 patients did not respond to cyclophosphamid. 28 patients received the cyclosporine - prednisone combinaison with a cyclosensibility in 23 patients [80 per cent]. The mycophenolate mofetil [MMF] was used in 7 patients, and 3 were in remission. In this study 7 patients [23 per cent] develop a chronic renal failure. the cyclophosphamid has not beneficial effects. The cyclosporine is an effective therapeutic agent. MMF has emerged as an important new therapeutic option for the treatment of SNCR and HSF