ABSTRACT
The effect of enflurane [Ethrane] anaesthesia on liver functions was studied on ten fit adult patients. There was a significant increase in serum enzymes [S.G.O.T. and S.G.P.T] and serum bilirubin, significant reduction in total serum proteins. However, inclination towards normal figures was noticed after 48 hours. It is concluded that hepatic dysfunction may follow enflurane anaesthesia in susceptible patients. When halothane and enflurane were introduced into clinical practice in 1956 and 1968 respectively it was assumed that they were inert substances eliminated from the body in an unchanged state[1]. It is now known, however, that some metabolic breakdown of these agents does occur and concern has been expressed that their biotransformation products may exert toxic effects on organs such as the liver and kidney[2]