High doses of buprenorphine in one-day opium detoxification: Clinical trial

The efficacy of high doses of buprenorphine prescription in one day was compared with the usual method. In a double-blind trial, 40 patients with the diagnosis of opioid dependence [based on DSM- IV criteria] were randomly assigned into two groups. 20 patients received 12 mg of buprenorphine intramuscularly in divided doses during one day long; 20 other patients were administered the usual decreasing doses of buprenorphine over five days. The followings were evaluated: success rate in detoxification, treatment retention in days, intensity of subjective withdrawal symptoms, intensity of objective withdrawal symptoms, level of drug craving, level of adjuvant drug use, drug side-effects, rate of positive urine tests for opioid, and levels of hepatic enzymes. Data were analyzed via statistical X2, t, Mann-Whitney, and Fisher tests. There was no significant difference between the two groups across most variables. The only difference observed was when the most withdrawal symptoms were evident, which was in the initial part of detoxification for the one-day treatment group and also at the end of the period for the five days treatment group. To shorten the detoxification period, the one-day and high doses of buprenorphine treatment can be beneficial even though further evaluations with a larger sample may be required. However, the use of injectable buprenorphine is not recommended in routine clinical practice, because of its possible abuse and serious side effects

Development, validation and reliability of child abuse self report scale [CASRS] in Iranian students

Diagnosing and assessing child abuse is a critical and difficult process in clinical psychology, because this phenomenon has several negative behavioral and psychological consequences on victims. The aim of this research is to create a scale for assessing child abuse and neglect. Through a multiclustral sampling, 3042 secondary school students [boys and girls] were selected to fill [1] a list of 54 items [Child Abuse and Self Report Scale, CASRS] which assess four categories of child abuse and neglect, after approving through content validity and [2] Trauma Symptom Checklist for Children [TSCC-A] in order to assign construct validity and comorbid psychopathology. Then, we did a clinical interview with a sample group who were diagnosed as abused children according to CASRS and TSCC-A. In addition, these scales were completed by a group of abused children as criterion group, for assigning criterion validity. In order to assign the reliability of CASRS and TSCC-A, after 3 weeks test-retest was done. Through a factor analysis, the best items were assigned. The results showed that CASRS and TSCC-A have excellent reliability and validity. Also, its stability was at an appropriate level. In addition, factor analysis showed that 38 items were the best questions for assessing child abuse. We believe that CASRS is an instrument which measures child abuse during the current life. It is brief [6 to 8 minutes for the core scales] and practical for epidemiological researches on child abuse, maltreatment and clinical screening. Methodological issues inherent in child self-report measures of abuse are discussed