ABSTRACT
From 11/1995 to 4/1999 we treated by prednisone for 15 patients and CsA for 16 ones with idiopathic aplastic anemia. Results:- Prednison did not change significantly TCD3, TCD4 and TCD8 colony count comparing with pre-treatment (P>0.05).- CsA decreased clearly TCD3 colony count after 1st, 6th month (P0.05). Conclusions: CsA has more suppressive effect on T-cell colonies, mainly TCDz3 and TCD8 than Prednisone and therefore it may be chosen to treat patients with idiopathic aplastic anemia without indication for bone marrow transplantation.
Subject(s)
Anemia, Aplastic , Therapeutics , Blood , Therapeutics , CyclosporineABSTRACT
From 11/95 to 11/97 we treated 27 patients with idiopathic aplastic anemia in which 13 treated with idiopathic aplastic anemia in which 13 treated with prednisolon and 14 cases with prednisolon. The results showed that the number of WBC, neutrophils and platelets have not increased in the group treated with cyclosporin A in the course of three months treatment. The group treated with cyclosporin A gave better than the results in comparison with group treated with prednisonlon after one month of treatment.
Subject(s)
Bone Marrow Diseases , Therapeutics , Cyclosporine , Blood PlateletsABSTRACT
After 2 months, more patients in the cyclosporine group had a complete or partial remission in response to the treatment than did patients in the prednison group (53,85% and 7,69%; P0,05. Hb concentration > 90g/l is 81,8% granulocyte counts >1,56G/l is 72,72%, platelet counts >100G/l is only 36,36%. 2 patients with responses in the cyclosponrine group relapsed after 24 months of treatment. Survival rate of patients in the cyclosporine group is 15/16 (93,57%) and in the prednison group is 6/15 (40%), P<0,05. Conclusion: Immunosuppressive treatment of aplastic anemia with cyclosponrine appears to be more effective than prednison and may represents a treatment of choice for patients with idiopathic aplastic anemia who are not eligible for bone marrow transplantation.