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1.
Indian J Pediatr ; 2009 Sept; 76(9): 950-951
Article in English | IMSEAR | ID: sea-142378

ABSTRACT

Functional follicular ovarian cysts are frequently reported in girls with peripheral precocious puberty (PP). These cysts are usually self-limiting and resolve spontaneously. Several drugs like antiestrogens (tamoxifen) and new aromatase inhibitors are seldom used for treatment. Here we report a girl with peripheral PP who presented with unilateral enlargement of the ovary and a recurrent autonomous ovarian cyst. No skin pigmentation or bone anomaly was noted. The patient was successfully treated with anastrozole, a highly selective aromatase inhibitor. No adverse reaction was noted. Anastrozole is a safe and tolerable drug especially used to suppress estrogen action.


Subject(s)
Aromatase Inhibitors/therapeutic use , Child , Female , Humans , Nitriles/therapeutic use , Ovarian Cysts/drug therapy , Puberty, Precocious/drug therapy , Recurrence , Triazoles/therapeutic use
2.
Indian J Pediatr ; 2008 Feb; 75(2): 186-8
Article in English | IMSEAR | ID: sea-80355

ABSTRACT

We report a 3-month-old male with infantile hypophosphatasia who later developed Pseudotumor cerebri. At the age of 3 months, he was referred to our hospital because of pneumonia and respiratory insufficiency. He had short extremities, and radiographs of the bones were consistent with lack of metaphyseal mineralization and bowed lower extremities. Vomiting and bulging fontanelle developed 3 months after admission, and CSF opening pressure was notably high at 430 mm/H2O. Hypophosphatasia is a very rare cause of pseudotumor cerebri. This report is the first case where PTC is associated with hypophosphatasia and responded well to corticosteroid therapy.


Subject(s)
Adrenal Cortex Hormones/therapeutic use , Humans , Hypophosphatasia/complications , Infant , Male , Pseudotumor Cerebri/complications , Respiratory Insufficiency/complications , Treatment Outcome
3.
Indian J Pediatr ; 2002 Dec; 69(12): 1087-9
Article in English | IMSEAR | ID: sea-79333

ABSTRACT

Neonatal diabetes mellitus (NDM) is defined as hyperglycemia occurring in the first few weeks of life. It can be either transient (TNDM) or permanent (PNDM). A 25 days old newborn was brought to the hospital with restlessness, respiratory depression and cyanosis. He was born at term with a birth weight of 2,000 g. There was no consanguinity between his parents. His physical examination findings were as follows: Weight and height were under 3th percentile, he was hypoactive and dehydrated. Serum glucose level was 800 mg/dl; C-peptide was 0.41 ng/ml. Upon investigation for dyslipidemia in association with his neonatal diabetes, hyperchylomicronemia was found both in the patient and his father. Pancreatitis, anemia and cholestasis were also observed. Insulin treatment was started for his diabetes together with a special diet for dyslipidemia. At the end of 28 months of follow-up, dyslipidemia has resolved but the need for insulin therapy was still existing. However, TNDM was considered in differential diagnosis because he was small for gestational age (SGA) at birth and his symptoms had started at the 25th day of the neonatal period. Delayed recovery from insulin dependency brought out the possibility of PNDM. Furthermore, neonatal diabetes combined with hypechylomicronemia is a rare clinical picture. Reported cases of NDM with different clinical evaluation will help to better understanding of this disorder.


Subject(s)
Diabetes Complications , Diabetes Mellitus/diagnosis , Diagnosis, Differential , Humans , Hyperlipidemias/complications , Infant, Newborn , Male
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