ABSTRACT
To investigate the ethanolic root bark extract of Icacina senegalensis for antinociceptive, anti-inflammatory and antipyretic activities in rats and mice. Acetic acid-induced abdominal constriction and tail immersion tests were used to evaluate the antinociceptive activity of the extract. Egg albumin and carrageenan-induced paw oedema were used to study the anti-inflammatory activity, whereas the anti-pyretic studies were evaluated on yeast and amphetamine-induced pyrexia. The root bark extract (50, 100 and 200 mg/kg) significantly (P<0.05) showed inhibitory activity for all the models in the antinociceptive, anti-inflammatory and antipyretic assayed. Result shows that ethanolic root bark extract of Icacina senegalensis possesses phytochemicals with therapeutic potential against painful, inflammatory and feverish conditions, and thus explain the use of Icacina senegalensis for similar ailments in traditional medicine.