Gender disparity in risk factors for chronic kidney disease in a rural community in Southern Nigeria

Background: The evidence for gender disparity in prevalence of CKD is conflicting; while some studies report male preponderance, others have report female preponderance or no difference. Reasons for gender disparities in CKD prevalence may be related to differences in the occurrence of risk factors across the gender, amongst other factors. This study was to determine gender disparities in the risk factors for CKD. Method: This study is based on data from a community based cross-sectional study carried out in Ogbona, a rural community in Southern Nigeria. The WHO STEPS for surveillance of chronic diseases risk factors and chronic disease-specific morbidity and mortality questionnaire was adapted for this study. Four hundred and seventy-six participants were selected from 142 housing units in the community using multi-stage cluster sampling. Clinical examinations and laboratory investigations including serum creatinine, and urinalysis were performed. Results: Majority of participants were females (66.2%). CKD was commoner in females compared to males (14.3% vs. 12.7%, P= 0.06). More females than males had high body fat percentages (65.7% vs. 40.9%, P=<0.0001), high waist-hip ratio (99.7% vs 73.3%, P=<0.0001) and central obesity (43.1% and 4.3% P=<0.0001). More males compared to females used alcohol (56% vs. 9.2%, P=<0.0001), were overweight (42.2% vs 28.9%, P=0.004), and had proteinuria (6.2% vs 2.5%, P=0.054). The odds of females having central obesity are 16.7 times the odds of males having central obesity; similarly, the odds of females having high BF are 2.7 times the odds of males having high BF. Females had 122-fold the odds of men having high WHR. The odds of drinking alcohol are 92% less compared to males. There were no statistically significant gender differences regarding hypertension, diabetes mellitus, and use of nephrotoxins (NSAIDS, skin lightening agents, herbal medications). No female smoked cigarettes. Conclusion: This study shows that there is no statistically significant gender difference as regards prevalence of CKD, however several risk factors of CKD show gender disparity. The odds for central obesity, high WHR, high body fat percentages are significantly greater in females; while smoking, alcohol use, and over weightness, are commoner in males. There were no statistically significant gender differences regarding hypertension, diabetes mellitus, and use of nephrotoxins (NSAIDS, skin lightening agents, herbal medications)

What does the medical student know about eye donation/corneal transplant? The University of Nigeria scenario / ¿Qué saben los estudiantes de medicina acerca de la donación de ojos/transplante de córnea? Panorama de la Universidad de Nigeria

OBJECTIVE: The study was designed to determine the knowledge of eye donation and corneal transplant among final year medical students of The University of Nigeria, Enugu Campus (UNEC). METHODS: Self-administered structured questionnaires were distributed to the members of the final year (graduating) class of the Medical College of UNEC in June 2007. Responses were obtained to questions bordering on eye donation and corneal transplant. RESULTS: One hundred and thirty-one students out of 183 eligible students participated in the study (response rate = 71.6%). One hundred and four students (79.4%) were aware of eye donation/corneal transplant. However, 95 students (72.5%) were not aware that the eyes can only be removed from a dead donor. Eight-yfour students (64.1%) were not aware that eyes with cataract could be donated. Eighty-seven (66.4%) students were not willing to pledge their eyes for donation. CONCLUSION: Medical students lack adequate knowledge about some aspects of eye donation and corneal transplantation. This may be a predictor of the level of awareness among the general public. Concerted innovative education and information dissemination strategies are required at this stage of national development to address the misconceptions surrounding eye donation and corneal transplant. There is a need to target medical students as future motivators, counsellors and eye donors. This should help advance the eye donation rates in Nigeria whenever the plans for the establishment of an eye-bank are finalized.

OBJETIVO: El estudio fue diseñado para determinar el conocimiento sobre la donación de ojos y el trasplante de la córnea entre estudiantes del último año de medicina en el Campus Enugu de la Universidad de Nigeria (UNEC). MÉTODOS: Se distribuyeron encuestas estructuradas auto-administradas entre los miembros de la clase del último año (graduandos) de la Facultad de Medicina de UNEC en junio de 2007. Se obtuvieron respuestas a preguntas en torno a la donación de ojos y el trasplante de córnea. RESULTADOS: Ciento treinta y un estudiantes de un grupo de 183 estudiantes elegibles, participaron en el estudio (tasa de respuesta = 71.6%). Ciento cuatro estudiantes (79.4%) conocían de la donación de ojos/trasplante de córnea. Sin embargo, 95 estudiantes (72.5%) no sabían que los ojos sólo pueden ser extraídos de un donante muerto. Ochenta y cuatro estudiantes (64.1%) no tenían conciencia de que se podían donar ojos con catarata. Ochenta y siete (66.4%) estudiantes no estaban dispuestos a ofrecer sus ojos para una donación. CONCLUSIÓN: Los estudiantes de medicina carecían de conocimientos adecuados sobre algunos aspectos de la donación de ojos y el trasplante de la córnea. Éste puede ser un predictor del nivel de conocimiento en el público general. Se necesita concertar una educación innovadora y estrategias de difusión de la información en esta fase de desarrollo nacional, a fin de abordar las concepciones erróneas en torno a la donación de ojos y el trasplante de córnea. Hay que hacer un trabajo de captación de los estudiantes de medicina como futuros motivadores, orientadores, y donantes de ojos. Esto debe contribuir a elevar las tasas de donación de ojos en Nigeria, en cuanto se concreten los planes para la creación de un banco de ojos.

Utility and Effectiveness of Computerised Motion Sensitivity Screening Tests in Rural Onchocercal Community Survey

BACKGROUND: Non-invasive tool of community diagnosis for onchocercal endemicity needs to be identified and ascertained for their utility and effectivity in order to facilitate the control of onchocerciacis in sub-Saharan Africa OBJECTIVE: To determine the utility and effectiveness of the Wu-Jones Motion Sensitivity Screening Test (MSST) in detecting optic nerve diseases in onchocercal-endemic rural Africa. METHODS: MSST was applied to sampled subjects in the selected communities of Raja in Sudan; Bushenyi in Uganda; Morogoro in Tanzania; and of Ikom; Olamaboro and Gashaka in Nigeria. Basically; six points within the central field of vision were repeatedly tested at 1/3 meter from the screen of a laptop computer in a room darkened. Motion sensitivity was expressed as a percentage of motion detected in the individual eye and this was averaged for the community. RESULTS: A total of 3;858 eyes of 2;072 patients were examined. Seventy-six percent of the subjects completed the test; at an average test time of 120.4 (66.7) seconds. The overall mean motion sensitivity of all eyes tested was 88.49 (17.49). At a cut-off point of 50; 6.4of all subjects tested were subnormal; while at 70cutoff; 13.3were subnormal. The highest proportion of 50cutoff sub-normality was recorded at Morogoro at 12.7. CONCLUSION: Motion Sensitivity Screening Test was widely accepted and easily administered to the rural and largely illiterate subjects studied. Our data suggest that the proportion of severe field defects by MSST in a community; with cutoff at 33; best correlates with optic nerve disease prevalence; while proportion of defect from a higher cut-off level at about 50; best correlates with overall ocular morbidity

The Undergraduate Training in Ophthalmology: The University of Nigeria Nsukka Medical Students

Objective: The study was embarked upon to determine the view of University of Nigeria final year medical students on the adequacy of their undergraduate training in ophthal- mology; vis-a-vis rendering basic eye care as general duty doctors. Methods: One hundred final year medical students; who had finished their ophthalmology clinical postings; completed a self-administered; structured and semi structured questionnaires in August 2004. Data analysis was done manually using an electronic calculator. Result: Majority of the students (60) were of the view that the training was inadequate. This was largely attributed to the low level of clinical exposure and community experience in the programme. Conclusion: The undergraduate training in ophthalmology undergone by these final year medical students may not have equipped them with adequate knowledge and skills to render basic eye care as general duty doctors. There is a need to improve the relevance and quality of the training.) were of the view that the training was inadequate. This was largely attributed to the low level of clinical exposure and community experience in the programme. Conclusion: The undergraduate training in ophthalmology undergone by these final year medical students may not have equipped them with adequate knowledge and skills to render basic eye care as general duty doctors. There is a need to improve the relevance and quality of the training

Apoc impact assessment study: baseline prevalence and distribution of ocular Onchocerciasis in three ecological zones in Nigeria

During the APOC/WHO Impact Assessment studies in Nigeria held in 1998 and 1999, one thousand and sixty four randomly selected subjects underwent detailed eye examination in three selected sites namely, Cross River State (rain forest ecological zone), Taraba State (savanna ecological zone) and Kogi State (forest- savanna ecological zone). The general objective of the impact assessment studies was to evaluate the ophthalmological impact of onchocerciasis control (CDTI) in Nigeria, this paper highlights the public health significance of ocular onchocerciasis in three different ecological zones in Nigeria. The presence of ocular onchocerciasis was established in all the study sites, with a predominance of posterior segment manifestations, in the rain forest zone. A blindness prevalenc e of 2.4o/o was recorded in the study, with onchocerciasis being responsible for 13 out of the 43 (30.2%) bilaterally blind subjects identified. Onchocerciasis-induced blindness prevalence was relatively high in the rain forest and forest savanna zones of Cross River and Kogi States with Cross River State having the highest site-specific- prevalence (5/10) 50.0% of onchocercal blindness followed by Kogr with (5/12) 41.7%. Taraba site recorded only 27.3% (3121). Other conditions identified included glaucoma, optic nerve disease and cataract rates of which were also found to be high among the population (6.90/o,6.5 % and8.9oh respectively). Anterior segment onchocercal lesions, punctate and sclerosing keratitis were the predominant features of the infection in Taraba site (14.1o/o and 6.3% respectively), a savanna zone while posterior segment lesions were much more common in the forest zone of Cross-River site. Visual field measurements reflected the predominant posterior segment disease. The need to sustain the present efforts aimed at controlling onchocerciasis through mass ivermectin distribution is fuither highlighted. Integration of other Eye Care Programme for the conffol of glaucoma and cataract, into the community directed treatment initiative of APOC for onchocerciasis control should also be strongly considered, in order to drastically reduce the prevalence and incidence of ocular morbidity and blindness, in Nigeria, especially in the onchocerciasis endemic areas.