ABSTRACT
RACIONAL: A base cirúrgica principal no tratamento do câncer colorretal é a remoção em bloco do tumor com adequadas margens proximal e distal, associada à remoção dos linfonodos mesentéricos. OBJETIVO: Avaliar fatores associados à quantidade de linfonodos encontrados em peças cirúrgicas de pacientes com câncer colorretal. MÉTODOS: Estudo retrospectivo, de pacientes consecutivos, operados com diagnóstico de adenocarcinoma colorretal. Foram excluídos aqueles submetidos ao tratamento cirúrgico paliativo. Os dados demográficos, operatórios e histopatológicos foram analisados utilizando os testes exato de Fisher, Qui-quadrado, Wilcoxon rank-sum e um modelo de regressão logística. RESULTADOS: No período de 2000 a 2008, foram operados 298 pacientes com câncer colorretal. Os dados incluídos na análise estavam disponíveis para 173 pacientes. Destes, 85 (49 por cento) eram do sexo feminino e a idade mediana era de 65 (26-94) anos. A ressecção mais comum foi a colectomia esquerda (45 por cento), seguida pela colectomia direita (23 por cento). O número mediano de linfonodos isolados foi oito (0-67) e 33 por cento dos pacientes tiveram 12 ou mais linfonodos identificados na peça cirúrgica. Os pacientes com idade menor que 50 anos e aqueles submetidos à coletomia direita obtiveram maior número de linfonodos isolados. CONCLUSÕES: A idade do paciente menor que 50 anos e o tipo de ressecção cirúrgica estão associados ao maior número de linfonodos encontrados nas peças cirúrgicas.
BACKGROUND: The main base in surgical treatment of colorectal cancer is en-bloc removal of the tumor with adequate proximal and distal margins, combined with the removal of lymph nodes. AIM: To evaluate factors associated with the number of lymph nodes found in surgical specimens from patients with colorectal cancer. METHODS: Analysis of a retrospective data of consecutive patients operated with a diagnosis of colorectal adenocarcinoma. Were excluded those undergoing palliative surgery. Demographic data, operative and histopathological findings were analyzed using the Fisher exact test, chi-square, Wilcoxon rank-sum and a logistic regression model. RESULTS: From 2000 to 2008, were operated 298 patients with colorectal cancer. The data included in the analysis were available for 173 patients. Of these, 85 (49 percent) were female and median age was 65 (26-94) years. The resection was the most common left colectomy (45 percent), followed by right colectomy (23 percent). The median number of lymph nodes were isolated from eight (0-67) and 33 percent of patients had 12 or more lymph nodes identified in surgical specimens. Patients younger than 50 years and those who underwent right colectomy had a greater number of lymph nodes isolated. CONCLUSIONS: Patient age less than 50 years and the type of surgical resection are associated with higher number of lymph nodes found in surgical specimens.
Subject(s)
Adult , Middle Aged , Aged, 80 and over , Adenocarcinoma , Colectomy , Neoplasm Staging , Lymph Nodes/surgery , Logistic Models , Colorectal Neoplasms/surgery , Retrospective StudiesABSTRACT
The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discussed with emphasis on toxic and anoxic attacks causing damage to endothelia, platelet depletion and alterations to hemostasia rates: prothrombin time [PT], partial thromboplastin time [PT] and Fibrinogen concentrations. The clinical-laboratory picture is compatible with the histopathological observation of disseminated intravascular coagulation [DIC] in most of the guinea pigs from day 4 of infection.
Subject(s)
Animals , Guinea Pigs , Hemorrhage/microbiology , Leptospirosis , SyndromeABSTRACT
Relata-se um caso grave de lípus eritematoso sistêmico que desenvolveu lesöes bolhosas durante a fase aguda da doença, obtendo excelente resposta à administraçäo de sulfona. Justificam o diagnóstico de lúpus eritematoso bolhoso pela história, apresentaçäo clínica e alteraçöes laboratoriais observadas. Discute-se a erupçäo bolhosa no lúpus eritematoso e fazem um breve histórico sobre o uso da sulfona no tratamento desta doença