Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters








Year range
1.
Rev. Soc. Bras. Clín. Méd ; 11(2)abr.-jun. 2013.
Article in Portuguese | LILACS | ID: lil-676606

ABSTRACT

JUSTIFICATIVA E OBJETIVOS: Tuberculose (TB) ainda é uma das principais infecções oportunistas em pacientes infectados pelo vírus da imunodeficiência humana (HIV). O objetivo deste estudo foi determinar a prevalência de tuberculose em pacientes portadores do HIV e estudar os fatores de risco associados.MÉTODO: Estudo retrospectivo do tipo descritivo e analítico.Pacientes atendidos entre janeiro de 2010 e abril de 2011no Serviço de HIV-AIDS da Santa Casa de Misericórdia de Vitória tiveram registrados dados demográficos, tabagismo,epidemiologia, contagem de células T CD4/CD8, carga viral HIV, terapia em uso e associação com TB.RESULTADOS: Foram analisados 715 pacientes. Destes,58,9% eram brancos, 59,9% homens, 59,3% heterossexuais,31,6% homo/bissexuais, 6,9% usuários de drogas injetáveis.A mediana de idade foi 44 anos e a do tempo de acompanhamento prévio de 5,7 anos. Havia 87% dos pacientes em uso de terapia antirretroviral e 32,7% eram tabagistas ou ex-tabagistas. Foi realizada quimioprofilaxia para TB em 6,7%dos pacientes. A mediana dos valores mais baixos da contagem de células CD4 foi de 191 células/mL. Foram relatados 80 casos de TB, prévios ou durante este período. Destes, 36casos foram de TB extrapulmonar, sendo 14 de forma miliar,12 ganglionar, cinco pleural, duas meníngea, duas óssea, uma pericárdica. Observou-se uma forte associação entre TB e o valor da contagem de células CD4 abaixo de 200 células/mL. Não foram observadas associações com escolaridade, idade,epidemiologia, cor ou carga viral HIV. Dois óbitos foram registrados em decorrência da TB. CONCLUSÃO: Constatou-se elevada a prevalência de TB entre pacientes HIV positivos, com nítida associação com o valor da contagem de células T CD4 abaixo de 200 células/mL.


BACKGROUND AND OBJECTIVES: Tuberculosis (TB) is still a major opportunistic infection in human immunodeficiency virus (HIV)-infected patients. The aim of this study was to report the prevalence of this disease in HIV-infected patients, its clinical presentation, and associated risk factors.METHOD: Retrospective cohort of HIV-infected patients attendedat the outpatient's clinic at Santa casa de Misericórdia de Vitoria between January 2010 and April 2011. Data were abstracted from medical records with demographics, smoking habits, epidemiology, T CD4/CD8 cells count, HIV viral load, therapy used and TB-associated disease. RESULTS: Seven hundred fifteen patients were studied. From these, 58.9% were white, 59.9% men, 59.3% with transmission by heterosexual intercourse, 31.6% bisexual men or men who had sex with men, 6.9% intravenous drug users. Median age was 44 years and median time since HIV diagnosis was 5.7 years. There were 87% of patients on antiretroviral therapy, and 32.7% were current or past smokers. Treatment for latent TB was prescribed for 6.7% of the patients. Median CD4 cells nadir was 191 cells/mL. Eighty cases of TB were recorded, previous or during the study period. Thirty-six cases were extrapulmonary TB, with14 being miliary, 12 ganglionary, five pleural, two meningitides, two bone, and one pericardial TB. There was a strong association between tuberculosis and CD4 cells bellow 200cells/mL. No association was observed with school years,age, epidemiology, race or HIV-1 viral load. Two death events were recorded as a consequence of TB. CONCLUSION: The prevalence of TB among HIV-infected patients remains high with a strong association with CD4cells count bellow 200 cells/mL.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Acquired Immunodeficiency Syndrome , AIDS-Related Opportunistic Infections/epidemiology , AIDS-Related Opportunistic Infections/immunology , Prevalence , Tuberculosis/epidemiology , Tuberculosis/immunology
SELECTION OF CITATIONS
SEARCH DETAIL