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1.
Araçatuba; s.n; 2016. 78 p. ilus, graf, tab.
Thesis in Portuguese | LILACS, BBO | ID: biblio-867939

ABSTRACT

Objetivos: Avaliar o potencial osteocondutor de quatro biomateriais utilizados no preenchimento de defeitos ósseos críticos em calvárias de coelhos. Material e métodos: 24 coelhos machos albinus foram submetidos à confecção de defeito ósseo de 8 mm de diâmetro na calvária bilateralmente. Os grupos foram divididos aleatoriamente pelos materiais utilizados: hidroxiapatita bovina - Biooss® (BIO), Lumina Bone Porus® (LBP) e Bonefill® (BFL) e, um material aloplástico - Clonos® (CLN), submetidos à eutanásia aos 14 e 40 dias após a cirurgia. A descalcificação das peças foi realizada e assim, as lâminas obtidas foram submetidas às análises histológica; análise histométrica, por meio da mensuração da área de osso neoformado (AON) no centro dos defeitos; análise imunoistoquímica, por meio da marcação do fator 2 de transcrição relacionado a Runt (Runx2), fator de crescimento do endotélio vascular (VEGF) e osteocalcina (OC). Os dados quantitativos foram submetidos à análise estatística (α=0,05). Resultados: O grupo CLN mostrou maior AON nos dois períodos analisados em relação aos demais grupos (p< 0,001, Teste Tukey). Aos 14 dias, o BIO foi superior quanto a AON aos grupos LBP e BFL, entretanto aos 40 dias, o grupo LBP superou os resultados do BIO (p< 0,001, Teste Tukey). A imunomarcação para Runx2 mostrou diminuição na intensidade para BIO aos 40 dias, enquanto que aumentou para LBP (p< 0,05, Teste Tukey). O CLN mostrou aumento para OC em comparação aos demais grupos em ambos os períodos analisados (p< 0,05, Teste Tukey). Conclusões: O CLN apresentou o melhor comportamento osteocondutor em defeitos críticos na calvária de coelhos


Objectives: To evaluate the osteoconductive potential of four biomaterials used in bone defects filling in rabbit’s calvaria. Methods: 24 male Albinus rabbits underwent to bone defect creation of 8 mm in diameter bilaterally in calvaria region. The groups were divided acordind to the bone substitute used to fill the calvaria defect: bovine hydroxyapatite - Bio-Oss® (BIO), Lumina Bone Porus® (LBP) and Bonefill® (BFL), and an alloplastic material - Clonos® (CLN), and were submitted to euthanasia at 14 and 40 days after the surgery. The removed pieces were processed, histological slides were obtained and subjected to histological analysis; histometric analysis, through the measurement of newly formed bone area (NB) in the center of the defects; immunohistochemical analysis, by labelling the Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF) and osteocalcin (OC). Quantitative data were statistically analyzed (α = 0.05). Results: The CLN group showed greater AON in both periods analyzed in relation to the other groups (p< 0.001, Tukey test). At 14 days, the AON showed greater values in BIO in relation with LBP and BFL groups, however , after 40 days, the LBP group surpassed the results of BIO (p< 0.001, Tukey test). The immunostaining showed a decrease in Runx2 intensity in BIO after 40 days, while it increased for LBP (p< 0.05, Tukey test). The CLN showed increased OC compared to the other groups in both periods analyzed (p< 0.05, Tukey test). Conclusions: The CLN showed the best osteoconductive behavior in critical defects in rabbit’s calvaria


Subject(s)
Animals , Rabbits , Biocompatible Materials , Bone and Bones , Bone Substitutes
2.
Araçatuba; s.n; 2016. 78 p. ilus, graf, tab.
Thesis in Portuguese | LILACS, BBO | ID: biblio-870137

ABSTRACT

Objetivos: Avaliar o potencial osteocondutor de quatro biomateriais utilizados no preenchimento de defeitos ósseos críticos em calvárias de coelhos. Material e métodos: 24 coelhos machos albinus foram submetidos à confecção de defeito ósseo de 8 mm de diâmetro na calvária bilateralmente. Os grupos foram divididos aleatoriamente pelos materiais utilizados: hidroxiapatita bovina - Biooss® (BIO), Lumina Bone Porus® (LBP) e Bonefill® (BFL) e, um material aloplástico - Clonos® (CLN), submetidos à eutanásia aos 14 e 40 dias após a cirurgia. A descalcificação das peças foi realizada e assim, as lâminas obtidas foram submetidas às análises histológica; análise histométrica, por meio da mensuração da área de osso neoformado (AON) no centro dos defeitos; análise imunoistoquímica, por meio da marcação do fator 2 de transcrição relacionado a Runt (Runx2), fator de crescimento do endotélio vascular (VEGF) e osteocalcina (OC). Os dados quantitativos foram submetidos à análise estatística (α=0,05). Resultados: O grupo CLN mostrou maior AON nos dois períodos analisados em relação aos demais grupos (p< 0,001, Teste Tukey). Aos 14 dias, o BIO foi superior quanto a AON aos grupos LBP e BFL, entretanto aos 40 dias, o grupo LBP superou os resultados do BIO (p< 0,001, Teste Tukey). A imunomarcação para Runx2 mostrou diminuição na intensidade para BIO aos 40 dias, enquanto que aumentou para LBP (p< 0,05, Teste Tukey). O CLN mostrou aumento para OC em comparação aos demais grupos em ambos os períodos analisados (p< 0,05, Teste Tukey). Conclusões: O CLN apresentou o melhor comportamento osteocondutor em defeitos críticos na calvária de coelhos.


Objectives: To evaluate the osteoconductive potential of four biomaterials used in bone defects filling in rabbit’s calvaria. Methods: 24 male Albinus rabbits underwent to bone defect creation of 8 mm in diameter bilaterally in calvaria region. The groups were divided acordind to the bone substitute used to fill the calvaria defect: bovine hydroxyapatite - Bio-Oss® (BIO), Lumina Bone Porus® (LBP) and Bonefill® (BFL), and an alloplastic material - Clonos® (CLN), and were submitted to euthanasia at 14 and 40 days after the surgery. The removed pieces were processed, histological slides were obtained and subjected to histological analysis; histometric analysis, through the measurement of newly formed bone area (NB) in the center of the defects; immunohistochemical analysis, by labelling the Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF) and osteocalcin (OC). Quantitative data were statistically analyzed (α = 0.05). Results: The CLN group showed greater AON in both periods analyzed in relation to the other groups (p< 0.001, Tukey test). At 14 days, the AON showed greater values in BIO in relation with LBP and BFL groups, however , after 40 days, the LBP group surpassed the results of BIO (p< 0.001, Tukey test). The immunostaining showed a decrease in Runx2 intensity in BIO after 40 days, while it increased for LBP (p< 0.05, Tukey test). The CLN showed increased OC compared to the other groups in both periods analyzed (p< 0.05, Tukey test). Conclusions: The CLN showed the best osteoconductive behavior in critical defects in rabbit’s calvaria.


Subject(s)
Animals , Rabbits , Biocompatible Materials , Bone and Bones , Bone Substitutes
3.
Braz. j. oral sci ; 9(1): 54-58, Jan.-Mar. 2010. ilus, tab
Article in English | LILACS, BBO | ID: lil-578048

ABSTRACT

Aim: This study compared the different views between orthodontists and oral maxillo facial surgeons,as for smile analysis in patients subjected to orthognathic surgery. Methods: Thirty individuals who had undergone orthognathic surgery and had a minimum postoperative period of 6 months were selected. Post treatment frontal smile photographs were obtained and examined. Smile features were recorded by 4 professionals (2 orthodontists and 2 surgeons) and the agreement between them was assessed. Results: The subjective analysis of smile as well as the observation of incisal and gingival exposure showed a statistically significant agreement percentage between the two groups. Nevertheless, no agreement was seen between the surgeons, while evaluating the buccal corridor and the parallelism between the incisal edge of antero-superior teeth and the lower lip. Significant agreement percentage (60%) was seen only between the orthodontists regarding the smile arch parallelism. Conclusions: Professionals must be alert as for facial analysis, mainly in terms of smile harmony, so that the orthognathic surgery will satisfactorily reestablish the facial esthetics in all the parameters outlined.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Esthetics, Dental/statistics & numerical data , Orthodontics , Orthognathic Surgical Procedures , Smiling , Gingiva , Treatment Outcome
4.
Ortodontia ; 40(4): 305-311, out.-dez. 2007. ilus, tab
Article in Portuguese | LILACS, BBO | ID: lil-542780

ABSTRACT

O nanismo radicular refere-se ao encurtamento radicular sem fator etiológico identificado. Manifesta-se simetricamente em dentes contralaterais, sendo a maior prevalência nos incisivos centrais superiores. Pode também afetar outros dentes ou até todos os dentes, recebendo a denominação de nanismo radicular generalizado. Ocorre com maior freqüência em mulheres e em orientais e tem etiologia genética. Sua presença não contra-indica o tratamento ortodôntico; contudo, exige cautela durante a mecanoterapia.


Short root anomaly consists of a shortening of the dental root without an identified etiology. It occurs symmetrically in contralateral teeth, with higher prevalence in the maxillary central incisors. However, it can also affect other teeth, or all the teeth, when it is called generalized short root anomaly. Women and orientals are more often affected, and its etiology is genetic. Such problem does not counter-indicate orthodontic treatment, but it requires caution during mechanotherapy.


Subject(s)
Humans , Orthodontics , Tooth Root/anatomy & histology , Tooth Root/abnormalities , Tooth
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