ABSTRACT
The current pandemic of COVID-19 (Coronavirus Disease-19), caused by the pathogen SARSCoV-2, leading to thousands of deaths in 2020, has mobilized the scientific community, with the purpose of understanding the different aspects of the disease and proposing new treatment and prevention measures. Research carried out in several areas includes evaluating the possibility of using hyperimmune globulin and monoclonal antibodies against SARS CoV-2 as well as analyzing the viability and efficacy of monoclonal antibodies and hyperimmune globulin in combating Sars-CoV-2. A literature review was carried out with a defined search strategy using the keywords (i) "hyperimmune globulin", (ii) "monoclonal antibody", (iii)" covid-19" and (iv)" sars-cov-2", in the PubMed and ResearchGate databases, using the bibliographic references of the articles selected in these databases. Of the 187 citations obtained, 10 articles published between 2019 and 2020 were selected after reading the summary of each one and determining its compatibility with the objective of this study. Final considerations highlight the main challenges and the feasibility of using hyperimmune globulin and monoclonal antibodies for the treatment/prevention of SARS CoV-2 infection.
Subject(s)
Humans , Coronavirus Infections , Betacoronavirus , Globulins , Antibodies, MonoclonalABSTRACT
Resumo A carga psicoemocional gerada com a morte de pacientes é uma das questões mais difíceis de serem enfrentadas na medicina. Este levantamento de dados, de caráter descritivo e abordagem quantitativa, teve como objetivo principal analisar a atitude de médicos e a percepção de estudantes de medicina em relação ao fim da vida. Os dados foram organizados em duas categorias: percepção dos entrevistados quanto à morte e influência da experiência médica para superar o óbito de enfermos. Os resultados mostram que os discentes se sentem despreparados para enfrentar essa realidade, e a vivência profissional é o principal fator de compreensão dos médicos sobre o tema. Conclui-se que a tanatologia e seus desdobramentos são lacuna na formação em medicina, tornando a morte questão crítica e dolorosa da profissão. Aprovação CEP-Fadip CAAE 68401717.6.0000.8063
Abstract The psycho-emotional pressure generated with the death of a patient is one of the most difficult issues to be faced in medicine. This survey aims to analyze how physicians and medical students perceive the end of life. The study was characterized as a data survey, with a descriptive and quantitative approach. The data were organized into two categories for analysis: perception of death; and the influence of the medical experience in facing patient death. The results show that students feel unprepared to face this reality and that the professional experience is the main modifying factor of the doctors' understanding of the death. It is concluded that thanatology and its unfoldings are part of an academic gap in medicine, and the confrontation of death is a painful issue for professionals. Aprovação CEP-Fadip CAAE 68401717.6.0000.8063
Resumen La carga psicoemocional generada por la muerte de pacientes es una de las cuestiones más difíciles a enfrentar en la medicina. Esta recolección de datos, de carácter descriptivo y de abordaje cuantitativo, tuvo como objetivo principal analizar la actitud de médicos y la percepción de estudiantes de medicina en relación con el fin de la vida. Los datos se organizaron en dos categorías: percepción de los entrevistados respecto de la muerte e influencia de la experiencia médica para superar la muerte de pacientes. Los resultados muestran que los estudiantes no se sienten preparados para enfrentar esa realidad, y la vivencia profesional es el principal factor de comprensión de los médicos sobre el tema. Se concluye que la tanatología y sus desdoblamientos son una laguna en la formación en medicina, tornando a la muerte una cuestión crítica y dolorosa de la profesión. Aprovação CEP-Fadip CAAE 68401717.6.0000.8063