ABSTRACT
This study was performed on 20 nonsmoking, normotensive type 2 female diabetic patients with normal renal and hepatic functions. They were divided into two groups: Group 1 included ten controlled type 2 diabetic patients on oral hypoglycemics with a mean age of 53.9 +/- 5.23 years [range 45-60 years] and mean diabetes duration of 5.7 +/- 2.6 years and group 2 included ten uncontrolled type 2 diabetic patients on oral hypoglycemics with a mean age of 49 +/- 5.01 years [range 40-56 years] and mean diabetes duration of 11.6 +/- 3.7 years. A determination of plasma insulin level using enzyme linked immunosorbent assay [ELISA] and the plasma level of plasminogen activator inhibitor-1 [PAI-1] was done using Biopool Tint Elize test. Ten age and sex matched normal subjects were included in the study as a control group. The results of this study indicated that among type 2 diabetic patients, PAI-1 was elevated among uncontrolled diabetic patients. It proved to have an important role in the development of ischemic heart disease as an example of macrovascular diabetic complication, especially if associated with dyslipidemia