Jejunal intussusception caused by a huge Vanek's tumor: a case report

Inflammatory fibroid polyp [known also as Vanek's tumor] is a type of localized, non-neoplastic inflammatory pseudotumor or inflammatory myofibroblastic tumor that occurs most commonly in the stomach but also in the small and large bowel. It is a documented cause of intussusception in adults. We report a case of a 40-year-old woman who presented with severe, postprandial abdominal pain followed by projectile vomiting over a period of three days. Ultrasonography demonstrated a solid and echogenic mass surrounded by the typical mural layers of an invaginated jejunum. She underwent urgent laparotomy and resection of an 18 cm tumor from the distal jejunum. The immuno-histopathological diagnosis after segmental jejunal resection was a jejunal inflammatory fibroid polyp. Although inflammatory fibroid polyps are seen very rarely in adults, they are among the probable diagnoses that should be considered in obstructive tumors of the small bowel causing intussusceptions

Lower gastrointestinal bleeding due to non-steroid anti-inflammatory drug-induced colopathy case report and literature review

The adverse effects of non-steroidal anti-inflammatory drugs [NSAIDs] on the upper gastrointestinal [GI] tract and small intestine are well established. The effect of such therapy on the large intestine, so called NSAID-induced colopathy, is less well described. NSAID-induced colopathy usually involves the right colon due to a higher concentration of the drug at this site, but the rectum may also be involved. NSAIDs possibly damage the normal large intestine, which presents as ulceration, colitis and stricture. Even though several studies found that NSAIDs can cause diverticular bleeding and perforation, flare-up of inflammatory bowel disease, and play a role as an etiologic factor in lymphocytic colitis. Inflammatory bowel diseases, malignancy and infectious colitis must be ruled out before establishing the diagnosis of NSAID -induced colopathy. Discontinuation of the offending drug is mandatory. Here, we have reported the case of a 43-year-old female, NSAID user due to low back pain, who was admitted to the hospital with painless hematochezia

Immunohistochemical expression of vascular endothelial growth factor and its correlation with tumor grade in breast ductal carcinoma

Breast cancer is the most common cause of cancer-related death in female, after lung cancer. Angiogenesis is essential for tumor growth and metastasis; therefore, antiangiogenesis strategies for treatment of cancer are currently an issue of interest. The role of vascular endothelial growth factor that assumed to be most potent angiogenesis factor is ambiguous in breast cancer. This study described the correlation between vascular endothelial growth factor expression and tumor grade, to define the breast cancer patients who responder to anti-vascular endothelial growth factor therapy. In this research, 200 cases of histological proved invasive ductal breast carcinomas analyzed for vascular endothelial growth factor expression by immunohistochemical staining via cross-sectional descriptive study. Vascular endothelial growth factor expressed in 72.54% of the breast cancers. The VEGF was more detectable in grade I [78.5%] than grade II [77.4%] and grade III [56.2%]. There is a significant correlation between tumor grade and VEGF expression [P<0.05]. According to this study, VEGF often expressed in invasive ductal breast carcinomas and inversely correlated with tumor grade. Anti-vascular endothelial growth factor postulated more convenience for tumor progression suppression in low grade tumor than high grade tumor

Microbiological pattern and risk factors of bacterial colonization in patients with clinically stable boronchiectasis

Background: Bronchiectasis, dilatation of bronchi with diameter more than 2 mm is a septic and inflammatory process of the lung, caused by infections and systemic or local defense abnormalities of tracheobronchial tree that may lead to destruction of bronchial wall. Infections usually cause inflammatory reaction and destruction of bronchial wall, this further leads to more disturbance in local defense and a vicious cycle of inflammation and bacterial colonization occurs. These bacteria divided to Potentially Pathogen Microorganism [PPM] or non-PPM. The purpose of this study was to find microbiologic pattern and associated [risk] factors in Iranian population and use of more narrow spectrum antibiotics

Materials and Methods: Forty patients with proven diagnosis of bronchiectasis by HRCT in a clinically stable condition fulfilled the inclusion criteria. Fiberoptic bronchoscopy was performed just after spirometry and BAL sampling was achieved. Cut off point of 10000 CFU was considered for positivity of culture media

Results: S. pneumoniae was the predominant pathogen. There was 85% rate of colonization by PPM. We found FEV1< 80% and FVC< 80% as risk factors for bacterial colonization by PPM and S. pneumoniae. Age of diagnosis <20 years was the additional risk factor for colonization of S. pneumoniae. Cystic bronchiectasis was predominant type of lesion and was more common in women

Conclusion: We have found some differences regarding the rate of colonization, number of patients with airflow limitation, and the predominant pathogen as compared with Western societies