ABSTRACT
Background Hp PUD is increasing. This study aimedto determine the trends of PUD andHp infection, and exposure to nonsteroid anti-infl ammatorydrugs and aspirin (NSAIDs/ASA), their association with upper gastrointestinal (UGI) bleeding, andcomparison to previous data.Methods Hp infection to previous data of 1992 to show their trends.Results Hp infection in each group was 38.18%, 42.86%, and 33.33%,respectively.Hp related ulcers had less UGI bleeding than NSAIDs/ASA related. When comparedto previous data, the proportion of DU had decreased, GU and combined ulcers had increased, andtheHp infection rate in all 3 groups had decreased.Conclusions Hp, non-NSAIDs/ASA related ulcers were diagnosed. NSAIDs/ASA related ulcers have morechances of bleeding.Chiang Mai Medical Journal 2010;49(2):41-48.While the prevalence of PUD and Hp was decreasing, more NSAIDs/ASA related andnon-A total of 98 cases were included; gastric ulcer (GU) in 55, duodenal ulcer (DU) in 28, and15 cases of combined ulcers. TheAll PUD patients with complete records of Hp status and NSAIDs/ASA exposure in 2008were included for analysis of prevalence and their association with UGI bleeding. We comparedpresent data of PUD andThe decline in global prevalence of Helicobacter pylori (Hp) and peptic ulcer disease(PUD) has been recognized, while the prevalence of non-