ABSTRACT
Although radioiodine (131-I) can be used as treatment of hyperthyroidism for patients in hemodialysis, its use is limited and the experience is mainly related to differentiated thyroid carcinoma. We report a 58 years old female on hemodialysis with recurrent hyperthyroidism after propylthiouracil treatment. She was successfully treated with 131-I and four months after the intervention her euthyroid state was confirmed. We measured 131-I activity in blood, dialysate liquid and other waste products, as well as patient radiation exposure rates. We found that 131-I elimination was prolonged through time with no major dependence on hemodialysis, as opposed to the elimination of 131-I in patients with thyroid carcinoma. This was probably due to high radiotracer uptake in hyper functioning thyroid tissue. Conversely, radiation content in dialysate wastes or equipment was minimal. Furthermore, the rate of both environmental exposure and exposure of nursing staff in charge of hemodialysis sessions, was minimal and met international security standards. In conclusion, I-131 therapy showed both appropriate effectiveness and safety in this case and may be considered as a suitable treatment alternative to thyroidectomy when antithyroid drugs are unsuccessful.
Subject(s)
Humans , Female , Middle Aged , Renal Insufficiency, Chronic/therapy , Hyperthyroidism/radiotherapy , Iodine Radioisotopes/therapeutic use , Renal Dialysis , Iodine Radioisotopes/pharmacokineticsABSTRACT
Comparamos la filtración glomerular obtenida del Renograma con DTPA (DTPA-GFR) con el clearance de creatinina (CC) y con la filtración glomerular calculada por formula de Schwartz (Schwartz-GFR). El interés por la (DTPA-GFR) deriva de la dificultad de obtener un resultado confiable de (CC) en la población pediátrica. Se estudiaron 47 pacientes, edad promedio 7 a 3m (1m - 18a7m), entre sep-2001 y mayo-2005. En todos se obtuvo (DTPA-GFR), (Schwartz-GFR) y en 18 de ellos se realizó además (CC). Se compararon las tres mediciones, separando grupos etarios. La mejor correlación se obtuvo al comparar el (DTPA-GFR) con el (CC) Pearson = 0,895. La correlación de (Schwartz) con (CC) mostró valores algo menores Pearson = 0,857 y la menor correlación se encontró al comparar (DTPA-GFR) con (Schwartz-GFR) en menores de 3 años Pearson = 0,560. Se concluye que la medición de (DTPA-GFR), muestra una leve mejor correlación con el clearance de creatinina que la estimación por el método de Schwartz y que podría considerarse un parámetro adicional de utilidad para evaluar la función renal en lactantes en los cuales es difícil realizar un Clearance de Creatinina.