ABSTRACT
The type of fluid used during resuscitation may have an important impact on tissue edema. We evaluated the impact of two different regimens of fluid resuscitation on hemodynamics and on lung and intestinal edema during splanchnic hypoperfusion in rabbits. The study included 16 female New Zealand rabbits (2.9 to 3.3 kg body weight, aged 8 to 12 months) with splanchnic ischemia induced by ligation of the superior mesenteric artery. The animals were randomized into two experimental groups: group I (N = 9) received 12 mL·kg-1·h-1 lactated Ringer solution and 20 mL/kg 6 percent hydroxyethyl starch solution; group II (N = 7) received 36 mL·kg-1·h-1 lactated Ringer solution and 20 mL/kg 0.9 percent saline. A segment from the ileum was isolated to be perfused. A tonometric catheter was placed in a second gut segment. Superior mesenteric artery (Q SMA) and aortic (Qaorta) flows were measured using ultrasonic flow probes. After 4 h of fluid resuscitation, tissue specimens were immediately removed for estimations of gut and lung edema. There were no differences in global and regional perfusion variables, lung wet-to-dry weight ratios and oxygenation indices between groups. Gut wet-to-dry weight ratio was significantly lower in the crystalloid/colloid-treated group (4.9 ± 1.5) than in the crystalloid-treated group (7.3 ± 2.4) (P < 0.05). In this model of intestinal ischemia, fluid resuscitation with crystalloids caused more gut edema than a combination of crystalloids and colloids.
Subject(s)
Animals , Female , Rabbits , Edema/etiology , Hydroxyethyl Starch Derivatives/administration & dosage , Ischemia/therapy , Isotonic Solutions/administration & dosage , Mesenteric Vascular Occlusion/therapy , Resuscitation/methods , Disease Models, Animal , Edema/pathology , Hydroxyethyl Starch Derivatives/adverse effects , Intestinal Diseases/etiology , Intestinal Diseases/pathology , Intestinal Mucosa/blood supply , Intestinal Mucosa/pathology , Ischemia/pathology , Isotonic Solutions/adverse effects , Lung Diseases/etiology , Lung Diseases/pathology , Mesenteric Vascular Occlusion/pathology , Random Allocation , Resuscitation/adverse effects , Severity of Illness Index , Splanchnic CirculationABSTRACT
Os autores avaliaram o efeito do tratamento ortopédico para correçäo de maloclusäo Classe II divisäo 1ª de Angle, e os resultados dessa correçäo, sobre a profundidade de sondagem do sulco gengival. Foram estudadas 26 crianças de 7 a 9 anos de idade de ambos os sexos, portadores desse tipo de maloclusäo, tratadas (13) e näo tratadas ortopedicamente (13), avaliadas quanto à profundidade de sondagem do sulco gengival na regiäo de incisivos superiores e inferiores, a intervalos de 3 meses por um período de 1 ano. Os dados obtidos submetidos à análise de variância, demostraram que o uso de ortopedia funcional influenciou na mensuraçäo da profundidade de sondagem com maiores valores para o grupo tratado, mantendo essa diferença mesmo após a correçäo da maloclusäo. Estes resultados levaram à conclusäo que a terapia com aparelhos ortopédicos contribui para maiores valores de profundidade de sondagem, provavelmente pelo efeito da movimentaçäo dentária, e que a correçäo da maloclusäo apesar de proporcionar melhor posicionamento de dentes e arcos, näo resultou em menores valores comparado ao grupo controle. Este efeito pode ser transitório, podendo ser minimizado ou desaparecer com a estabilizaçäo da posiçäo dentária e a instituiçäo de medidas efetivas de higiene e controle da placa bacteriana