1.
Arch. venez. farmacol. ter
;
8(1): 66-71, 1989. ilus
Article
in Spanish
| LILACS
| ID: lil-79096
ABSTRACT
Seven healthy adult volunteers participated in a cross over desing multiple dose biovailability study to test steady state pharmacokinetics of a new sustained rekease suspension dosage form of micro-encapsulated theophylline (TEOBID Suspension 300 mg/5 ml) in comparison to a sustained release theophylline tablet (TEOBID 300 mg tablets). The pharmacokinetic parameters AUC 0-12 (ss), Cmax (ss) and Cmin (ss) as well as the percentage flutuation in serum concentrations over a 12 hours dosage interval tested by univariate one way ANONA showed no significant differences (p < 0.05) between the two products