ABSTRACT
Fourty male mature albino rats divided into 4 equal groups, a control and three test groups, were used in this experiment to evaluate the effect of praziquantel on the humoral murine immunity and testosterone hormone. The drug was introduced orally once, twice, and thrice in the first, second and third test groups respectively with an interval of ten days between the doses in the last two test groups. Sheep red blood cells were then injected intra-peritoneally on the O and 21 days of the last drug administration, after 30 days the anti-body titre against sheep erythrocytes was measured by using the tube agglutination method, also the testosterone level was detected in the sera of the control and third groups by using radio-immunoassay method. No statistical changes were observed although the mean antibody titre and testosterone hormone increased in the third test group. This denote that praziquantel has no depressive effect on the antibody formation and the decrease in the antibody titre after praziquantel treatment in infected hosts may be due to binding of these antibodies to eggs and/or worm antigens producing circulating immune complexes leading to the clearance of these antigens from the vasculature. At the same time, the drug has also no effect on the blood testosterone level