ABSTRACT
@#Introduction: This study aimed to investigate the prevalence, risk factors, and clinical outcomes of Inflammatory Bowel Disease (IBD) in Mosul Hospital, Iraq, in 2022. Methods: A cross-sectional study design was used to collect data from patients diagnosed with IBD in Mosul Hospital. A questionnaire was used to collect demographic and clinical data, including risk factors, symptoms, and treatment outcomes. Data were analyzed using descriptive statistics and logistic regression. Results: The study included 150 participants, with a mean age of (42.5. ± years and 56% being male. Women were found to be less likely to know the type of Crohn’s disease compared to men. 58.7% of participants did not have any other diseases, while 41.3% had multiple diseases. The CH type was known for 56.8% of participants, and the average disease duration was 70.41 months, ranging from 2 to 360 months. Most participants (72.1%) did not have involvement in a particular place, while 27.9% did. All participants had known involvement. 81.8% of participants did not use drugs, while 18.2% did, with partial or unknown drug usage reported in 39 individuals. Only 7.8% of participants had IBD in their family, while 92.2% did not. Most participants (95.2%) were smokers. Conclusion: The study highlights the need for increased awareness and early detection of IBD in Mosul Hospital. The identification of risk factors and symptoms can aid in the diagnosis and management of the disease. Further research is necessary to understand the underlying causes of IBD and to develop effective prevention and treatment strategies.
ABSTRACT
The present work to evaluate whether there is a significant relationship between atherosclerosis and Chlamydophila Pneumoniae [C. pneumoniae] infection by using the Enzyme Linked Immunosorbent Assay [ELISA] techniques to detect the antibodies, and polymerase chain reaction [PCR] to detect the microbial DNA. Case-control study was carried out on atheromatous plaque and serum samples obtained from 74 patients with peripheral arterial disease caused by atherosclerosis and another 14 patients with varicose veins as a control group in the Vascular Surgery Department, Sohag University Hospital over a period between October 2013 and June 2014. Chlamydophila pneumoniae DNA was extracted, amplified and detected using PCR assay, and anti C. pneumoniae IgG antibodies were detected by ELISA assay. Both ELISAandPCR techniques were done for the studied cases and the control group. ELISA technique was positive for Chlamydophila pneumoniae IgG antibody in 40 patients [54.05%] among the studied cases while in the control group, it was positive only in 4 cases [28.57%] with p-value 0.08. PCR technique was positive in 28 patients [37.84%] in the cases for Chlamydia pneumoniae 16sRNA gene, while for the control group, all cases were negative with p- value 0.005. Conclusions: Chlamydophila pneumoniae infection can be considered as a strong risk factor for atherosclerosis