ABSTRACT
Amelogenins from ameloblast play an important rule in differentiating odontoblasts in dental papilla, suggesting that amelogenins may associate with odontoblasts changes during development. Aim In the present study we have investigated the effects of enamel matrix derivative [EMD] on the healing of pulpal wound and formation of reperative dentin. Sixty human premolars scheduled for orthodontic extraction were divided into two groups. Coronal pulp tissue was exposed after class V buccal cavity preparatin. Under rubber dam isolation, the exposed pulps in group one were capped by Emdogain [Biora AB, Malmo, Sweden], and the other group served as controls and were capped by calcium hydroxide past [Dycal]. The cavities in both groups were sealed by glass-ionomer cement [Ketec fill]. After 2 weeks, 4 weeks and 2 months teeth were extracted [10 teeth for every interval] and prepared for histopathological study. In EMD- treated teeth, Rapid formation of new dentin-like hard tissue was observed and significant statistical was found from control group [p