Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry / 药物分析学报

A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of heated nitrogen was used to thermally desorb analytes to gas phase. The desorption temperatures were sometimes as low as 50 1C. For example, negative-ion spectra recorded from an aspirin tablet showed peaks at m/z 137 (salicylate anion) and 179 (acetylsalicylate anion) which were absent in the background spectra. The overall ion intensity increased as the desorption gas temperature was elevated. Within the same acquisition experiment, both positive- and negative-ion signals for acetaminophen were recorded from volatiles emanating from Tylenol tablets by switching the polarity of the capillary back and forth. Moreover, different preparations of acetaminophen tablets could be distinguished by their ion-intensity thermograms.

Relación de patología y virósica y tumoral respecto a los papanicolaou obtenidos de una población de pacientes ginecológicas y obstétricas en el Hospital Materno Provincial de Córdoba en un período de dos años / Relationship of viral and tumor pathology and about the pap smear obtained from a population of gynecological and obstetric patients the Cordoba Provincial Maternity Hospital over a period of two years

INTRODUCCIÓN: El cáncer cervical afecta a un número sustancial de mujeres en edades activas. En la mayor parte del continente africano, Centro y Sudamérica, el cáncer de cérvic representa de 20 a 30%. No se conoce con certeza el tiempo que se requiere para que una lesión beningna evolucione hasta un cáncer in situ. Los papilomavirus constituyen un grupo de virus pequeños de ADN de aproximadamente 55 nm, que inducen tumores epiteliales escamosos. Constituyen más de 100 tipos de virus humanos. Todos se vinculan con lesiones confinadas a las capas epiteliales de la piel o las mucosas. Aproximadamente 40 diferentes tipos infectan el tracto genital y de ellos más de 20 se asocian con cáncer. OBJETIVOS: Detectar de patologías cervicales por screening de papanicolaou en la población de pacientes. Descubrir signos indirectos de infección por papiloma Virus Humano y CIN en pacientes embarazadas, no embarazadas y adolescentes. Validar datos obtenidos durante dos años de seguimiento.