ABSTRACT
Obesity is a serious medical condition worldwide, which needs new approaches and recognized international consensus in treating diseases leading to morbidity. The aim of this review was to examine heterogeneous links among the various phenotypes of obesity in adults. Proteins and associated genes in each group were analysed to differentiate between biomarkers. A variety of terms for classification and characterization within this pathology are currently in use; however, there is no clear consensus in terminology. The most significant groups reviewed include metabolically healthy obese, metabolically abnormal obese, metabolically abnormal, normal weight and sarcopenic obese. These phenotypes do not define particular genotypes or epigenetic gene regulation, or proteins related to inflammation. There are many other genes linked to obesity, though the value of screening all of those for diagnosis has low predictive results, as there are no significant biomarkers. It is important to establish a consensus in the terminology used and the characteristics attributed to obesity subtypes. The identification of specific molecular biomarkers is also required for better diagnosis in subtypes of obesity.
ABSTRACT
Presentamos tres casos de dermatitis irritativa de la zona del pañal de aparición poco común, el eritema pápulo-erosivo de Sevestre-Jacquet y el granuloma glúteo infantil, que junto con la erupción pápulo-nodular pseudo-verrucosa perianal, son raras variedades morfológicas de esta frecuente entidad. Se consideran presentaciones patológicas de la dermatitis irritativa del área del pañal, con un amplio espectro de manifestaciones clínicas.
We present three cases of dermatitis of the diaper area of rare occurrence, papulo-erosive erythema of Sevestre-Jacquet and granuloma gluteale infantum, which together with the perianal pseudo-verrucous papules and nodules, are very rare morphological varieties of clinical manifestation of this common entity. These pathological presentations are considered as part of a wide spectrum of clinical manifestations of irritative dermatitis in the diaper area.
ABSTRACT
Se presenta el caso de un escolar con febrícula y leve ataque del estado general, quien desarrolla una erupción maculosa en mejillas, pocos días después un exantema en "encaje" o reticulado en tronco posterior y parte proximal de extremidades inferiores, compatible con la quinta enfermedad y confirmado por la morfología lesional característica y la inmuno-serología (IgM).
We present a five years old child with a mild fever and malaise, a maculoedematous eruption on cheeks and a "lace" exanthema located on posterior aspect of the trunk and lower limbs, developed after a few days. A fifth disease was diagnosticated based on characteristic morphological presentation and immunoserological studies.