ABSTRACT
Diabetes mellitus is associated with an increased risk of cardiovascular disease, even in the presence of intensive glycaemic control. Both diabetes and insulin resistance bring about a amalgam of endothelial dysfunction and it will abate the anti-atherogenic role of the vascular endothelium. In patients with type 2 diabetes both insulin resistance and endothelial dysfunction appear to lead up to the development of undisguised hyperglycaemia. Hence, in patients with diabetes, endothelial dysfunction may be a censorious early intention for preventing atherosclerosis and cardiovascular disease. For the assessment endothelium- dependent vasodilatation Coronary and peripheral circulations are used. In Ayurveda, endothelial dysfunction can be correlated to Rakthavaha srotho dushti. There are several aetiological factors similar in both Prameha and Rakta dushti. The factors which got vitiated (Dooshya) in Prameha are Mamsa, Meda, Rasa, Rakta, Shukra, Lasika, Vasa, Majja & Oja. Amongst all Meda & Mamsa are main vitiated factors (Dooshya) while Rakta is one of the Dooshya initially. During nourishment, Rakta is nourished prior to Meda & Mamsa. Further it nourishes Meda dhatu too. Endothelial dysfunction is reversible in early stages so that many rasayana drugs mentioned in the Ayurveda can be used here. In the present review briefly outlines some basic concepts of endothelial structure and function, and its dysfunction, relation with diabetes and its Ayurvedic concepts and management.
ABSTRACT
Cutaneous T cell lymphoma (CTCL) are a rare group of diseases caused by uncontrolled proliferation of T cells which belongs to mature T cell lymphoma having indolent nature. Two thirds of the CTCL are comprised of Mycosis Fungoides (MF) and Sezary Syndrome (SS). They are characterized by macules and patches which on later progresses to tumors or nodules with adenopathy and other organ infiltration. If left untreated the risk of developing infection increases with visceral involvement of skin, GI tract, lungs and adrenals. Diagnosis is done by histopathological appearance, cytogenetic analysis, etiology and the functional biology of neoplastic cells. Imaging techniques (MRI and CT) are widely done to assess the staging of disease and other tissue involvement. Radiotherapy, chemotherapy and retinoids have been in use since long time, but possess many side effects. According to Ayurveda, CTCL can be caused by Ahara like Virudha, Agantuja bhavas, Beeja-beejabhaga-beejabhagavayava dushti and Ojas/bala hani. The clinical features can be related with Kushta and in later stage simulates Dhatugata kushta and Granthi-arbuda. The etiopathogenesis of CTCL can be considered as formation of Ama, Agnimandhya, Srothovaigunya, and Balahani. Management will be preventive, curative and palliative with Sodhana, Samana and Rasayana therapies