ABSTRACT
IL-6 levels are significantly elevated in COVID-19 patients and are associated with poor clinical outcomes. Inhibiting IL-6 is thought to be a unique therapeutic strategy for the control of dysregulated host responses in SARS-CoV-2. The present study focuses on evaluating the research productivity of IL-6 level in SARS-CoV-2 infection using various bibliometric indicators and analysed 4510 research papers related to IL-6 levels in SARS-CoV-2 from the Scopus database and VOSViewer© tool applied for visualization. The results revealed that ascendant trends in the publications and USA, China and Italy have secured top three position in numbers of publications. Study observed that “Dagna L.” received top prolific author rank. Article entitled “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China” received maximum of 15364 total citations, whereas “Frontiers in Immunology” and “Journal of Medical Virology” secured in top two highly productive journals in the subject with extreme link strength. With regard to organisation, “Tongji Medical College-China” reported highly dynamic organization. “Covid-19”; “SARS-Cov-2”; “Interleukin” received maximum occurrences with high link strength. In view of global mounting public health issue of COVID-19, primarily due to increased viral transmissibility and associated cytokine storm, the present study will helpful for the medical professionals to know the research trends and also library authority for updating collection development policy in the specific subject domains.
ABSTRACT
Objective: To evaluate sexually transmitted infections [STI] with reference to its pattern and any change in the trend of STI
Methods: The present work was designed as a tertiary urban hospital based observational, cross-sectional, clinico-demographic study during the period from Feb 2013 to Sep 2014. Patients were examined clinically and relevant investigations were done
Results: Out of total 178 STI patients, the commonest STI was balanoposthitis [n=65, 36.5%] followed by genital scabies [n=31, 17.4%], genital herpes [n=19, 10.7%,], venereal warts [n= 15, 8.4%], nongonococcal urethritis [n= 14, 7.9%] and chancroid [n=12, 6.7%]. Majority of the patients [n= 46, 25.8%] were in the age group 25-29 years and the younger patients [ages 15-24 years] constituted a bulk of 58 [32.6%]. HIV seropositivity was seen in 7 [3.9%] of total STI cases. Among HIV seropositive patients herpes genitalis [n=4, 57.1%] were most common STI. Commercial sex workers [n=78, 43.8%] were the main source of infection responsible for STIs
Conclusion: The present study showed the changing trend of STIs. The current scenario has changed with balanoposthitis being the most common STI. A decline in the number of younger patients between the age group of 15 to 24 years suggested a shifting pattern from adolescent to adult age group
ABSTRACT
Aim: To assess outcome of chemoradiotherapy for organ preservation in muscle invasive bladder cancer
Material and Methods: 41 patients treated between January 2010 to January 2015 were evaluated in the present study. All patients T staged ranging from cT2-T4a and had undergone maximal transurethral resection of bladder tumour [TURBT]. After maximum bladder tumour resection patients were treated with Radiotherapy with or without concurrent chemotherapy. 8 weeks after completion of treatment response was assessed by check cystoscopy, urine cytology and CECT scan Abdomen. Data regarding the toxicity profile, initial complete response rates at 3 months, occurrence of loco regional or distant failure and survival was recorded
Results: Age ranged between 45- 84 years, [mean age 65.44]. Radiotherapy dose planned ranged from 60 Gy/30fr to 70.3 Gy/37 fractions to primary target and 59.2 Gy/37fractions to the nodal disease. PTV volume ranged from 69-548.9 cc. 23 patients received concurrent chemotherapy weekly. 11 patients have cystitis [5 Gr 1, 4 Gr II and 2 Gr III]. 5 patients have myelosuppression. 10 patients have acute gastrointestinal toxicity [5 Gr-I, 4 Gr-II, 1 Gr-III]. At the time of analysis follow up ranged from 3-42 months [median follow 1 year].The DFS at 42 months was 54%. Out of 39 patients 3 were lost to follow up [2 in partial bladder group and 1 in whole bladder group]. Out of 36 patients 24 [66.6%] are disease free, 4 [11.1%] patients had recurrence for which 2 underwent salvage cystectomy whereas 2 patients received palliative chemotherapy. Five patients developed distant metastases [4 bone and 1 brain metastasis]
Conclusion: Bladder-preservation therapy for muscle-invasive bladder cancer is a valid substitute in selected cases with long-term efficacy similar to radical cystectomy, with the additional advantage of preserving excellent bladder function in the majority of long-term survivors
ABSTRACT
We herein report a case with multifocal cysticercosis-sub-conjunctival cysticercus cyst, sub-retinal cysticercosis, and neurocysticercosis in a child. The optical coherence tomography [OCT] findings of the sub-retinal cysticercus cyst are reported. He was treated with anti-helminthic drugs and oral prednisolone followed by surgical removal of the sub-retinal cyst. He subsequently underwent silicone oil removal with lens aspiration and intraocular lens implantation maintaining stable vision
ABSTRACT
To analyze the outcome of combined scleral buckling and phacoemulsification for primary rhegmatogenous retinal detachment and visually significant cataract. Retrospective, interventional case series. Retrospective review of patients with primary rhegmatogenous detachment with or without proliferative vitreoretinopathy [PVR] changes and visually significant cataract who underwent combined scleral buckling and phacoemulsification with or without intraocular lens [IOL] implantation between 1991 and 2006. Of the ten eyes, all underwent phacoemulsification and five eyes had posterior chamber Intraocular lens [PC IOL] implantation. All eyes underwent scleral buckling with solid silicone explant combined with #240 encircling band. Subretinal fluid [SRF] drainage was done in five eyes Four eyes improved to better than 6/12 at a mean follow-up of 9 months. Anatomical success was achieved in all eyes [100%]. Combined scleral buckling and phacoemulsification is a safe and effective procedure that spares the patient the burden of repeated surgeries. It may be considered as a treatment option in selected cases of rhegmatogenous retinal detachment with significant cataract with/without early PVR