ABSTRACT
Topical metronidazole [10 percent] has been previously demonstrated to decrease post operative pain after hemorrhoidectomy. The aim of this study was to evaluate the effect of topical metronidazole [10 percent] on postoperative and after defecation pains of hemorrhoidectomy. A double-blind randomized trial was conducted to compare post- hemorrhoidectomy pain using topical metronidazole [10 percent] to. placebo carrier applied to surgical site. Forty-seven patients were randomly selected to receive metronidazole [n=25] or placebo [n=22]. Pain was assessed using a visual analog scale [VAS] preoperatively as well as on postoperative hours 6 and 12, and on days 1, 2, 7, and 14. The use of narcotic, additional analgesics and complications were recorded. [Pain scores were calculated and compared with baseline values and control group [t-test, SPSS ver.10]. Patients in the topical metronidazole group had significantly less postoperative pain than those in the placebo group by the day 14 [P = 0.04]. There was no significant difference in narcotic analgesic requirements between groups, except for hour 12 [P<0.05]. In the metronidazole group, after defecation, pain was ranked significantly lower on day 2 [P=0.016] and patients required fewer additional analgesics postoperatively on days 2 and 7 [P = 0.04]. These finding indicate that topical 10 percent metronidazole significantly reduce post- hemorrhoidectomy discomfort and postoperative defecation pain is reduced compared with that of the placebo control group