Osteosarcoma of breast - A case report

Sarcoma of breast is usually of the spindle cell variety. They arise from intracellular fibroadenoma or follow previous radiotherapy. Unusal bone forming sarcoma are rare entity especially osteosarcoma in pure form is seldom seen. We are reporting a case of osteosarcoma of the breast. The patient underwent radical modified mastectomy and received post operative adjuvant chemotherapy. She is presently disease free with a follow up of 5 months

Comparison of two neoadjuvant infusion chemotherapy regimens in advanced squamous cell carcinoma of head and neck

Between 1987-1992 thirty three patients of stage lll and lV squamous cell carcinoma of the head and neck were randomised into two groups, group I comprised of 18 patients and received cisplatinum and 5 fluorouracil as neoadjuvant infusion chemotherapy. Group II had 15 patients and received bleomycin, cisplatinum and 5 flurouracil as neoadjuvant infusion chemotherapy. The total response rates in both the groups were similar: group I: 83.3% and group II: 86.6%. Patients in GpII tend to achieve a response with only two cycles of chemotherapy. The addition of bleomycin in regime II probably helps to reduce the number of chemotherapy cycles from three to two to achieve a complete partial response. The toxixcity of both these regimens is mild and clinically acceptable